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The caspase-1 inhibitor AC-YVAD-CMK attenuates acute gastric injury in mice: involvement of silencing NLRP3 inflammasome activities

This study evaluated the protective effects of inhibiting caspase-1 activity or gastric acid secretion on acute gastric injury in mice. AC-YVAD-CMK, omeprazole, or vehicle were administered to mice before cold-restraint stress- or ethanol-induced gastric injury. Survival rates and histological evide...

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Detalles Bibliográficos
Autores principales:	Zhang, Fang, Wang, Liang, Wang, Jun-jie, Luo, Peng-fei, Wang, Xing-tong, Xia, Zhao-fan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823746/ https://www.ncbi.nlm.nih.gov/pubmed/27053298 http://dx.doi.org/10.1038/srep24166

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