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Improving the catalytic activity of isopentenyl phosphate kinase through protein coevolution analysis
Protein rational design has become more and more popular for protein engineering with the advantage of biological big-data. In this study, we described a method of rational design that is able to identify desired mutants by analyzing the coevolution of protein sequence. We employed this approach to...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823809/ https://www.ncbi.nlm.nih.gov/pubmed/27052337 http://dx.doi.org/10.1038/srep24117 |