4D nucleomes in single cells: what can computational modeling reveal about spatial chromatin conformation?

Genome-wide sequencing technologies enable investigations of the structural properties of the genome in various spatial dimensions. Here, we review computational techniques developed to model the three-dimensional genome in single cells versus ensembles of cells and assess their underlying assumptio...

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Detalles Bibliográficos
Autores principales: Sekelja, Monika, Paulsen, Jonas, Collas, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823877/
https://www.ncbi.nlm.nih.gov/pubmed/27052789
http://dx.doi.org/10.1186/s13059-016-0923-2
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author Sekelja, Monika
Paulsen, Jonas
Collas, Philippe
author_facet Sekelja, Monika
Paulsen, Jonas
Collas, Philippe
author_sort Sekelja, Monika
collection PubMed
description Genome-wide sequencing technologies enable investigations of the structural properties of the genome in various spatial dimensions. Here, we review computational techniques developed to model the three-dimensional genome in single cells versus ensembles of cells and assess their underlying assumptions. We further address approaches to study the spatio-temporal aspects of genome organization from single-cell data.
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spelling pubmed-48238772016-04-08 4D nucleomes in single cells: what can computational modeling reveal about spatial chromatin conformation? Sekelja, Monika Paulsen, Jonas Collas, Philippe Genome Biol Review Genome-wide sequencing technologies enable investigations of the structural properties of the genome in various spatial dimensions. Here, we review computational techniques developed to model the three-dimensional genome in single cells versus ensembles of cells and assess their underlying assumptions. We further address approaches to study the spatio-temporal aspects of genome organization from single-cell data. BioMed Central 2016-04-07 /pmc/articles/PMC4823877/ /pubmed/27052789 http://dx.doi.org/10.1186/s13059-016-0923-2 Text en © Sekelja et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Sekelja, Monika
Paulsen, Jonas
Collas, Philippe
4D nucleomes in single cells: what can computational modeling reveal about spatial chromatin conformation?
title 4D nucleomes in single cells: what can computational modeling reveal about spatial chromatin conformation?
title_full 4D nucleomes in single cells: what can computational modeling reveal about spatial chromatin conformation?
title_fullStr 4D nucleomes in single cells: what can computational modeling reveal about spatial chromatin conformation?
title_full_unstemmed 4D nucleomes in single cells: what can computational modeling reveal about spatial chromatin conformation?
title_short 4D nucleomes in single cells: what can computational modeling reveal about spatial chromatin conformation?
title_sort 4d nucleomes in single cells: what can computational modeling reveal about spatial chromatin conformation?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823877/
https://www.ncbi.nlm.nih.gov/pubmed/27052789
http://dx.doi.org/10.1186/s13059-016-0923-2
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