Glycerol-3-phosphate acyltransferase-1 upregulation by O-GlcNAcylation of Sp1 protects against hypoxia-induced mouse embryonic stem cell apoptosis via mTOR activation

Oxygen signaling is critical for stem cell regulation, and oxidative stress-induced stem cell apoptosis decreases the efficiency of stem cell therapy. Hypoxia activates O-linked β-N-acetyl glucosaminylation (O-GlcNAcylation) of stem cells, which contributes to regulation of cellular metabolism, as w...

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Detalles Bibliográficos
Autores principales: Lee, H J, Ryu, J M, Jung, Y H, Lee, K H, Kim, D I, Han, H J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823928/
https://www.ncbi.nlm.nih.gov/pubmed/27010859
http://dx.doi.org/10.1038/cddis.2015.410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823928/
https://www.ncbi.nlm.nih.gov/pubmed/27010859
http://dx.doi.org/10.1038/cddis.2015.410

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