Critical B-lymphoid cell intrinsic role of endogenous MCL-1 in c-MYC-induced lymphomagenesis

Evasion of apoptosis is critical for tumorigenesis, and sustained survival of nascent neoplastic cells may depend upon the endogenous levels of pro-survival BCL-2 family members. Indeed, previous studies using gene-targeted mice revealed that BCL-XL, but surprisingly not BCL-2, is critical for the d...

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Detalles Bibliográficos
Autores principales: Grabow, S, Kelly, G L, Delbridge, A R D, Kelly, P N, Bouillet, P, Adams, J M, Strasser, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823944/
https://www.ncbi.nlm.nih.gov/pubmed/26962682
http://dx.doi.org/10.1038/cddis.2016.43

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