Functional genetics-directed identification of novel pharmacological inhibitors of FAS- and TNF-dependent apoptosis that protect mice from acute liver failure

shRNA-mediated gene-silencing technology paired with cell-based functional readouts reveals potential targets directly, providing an opportunity to identify drugs against the target without knowing the precise role of the target in the pathophysiological processes of interest. By screening a lentivi...

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Detalles Bibliográficos
Autores principales: Komarov, A P, Komarova, E A, Green, K, Novototskaya, L R, Baker, P S, Eroshkin, A, Osterman, A L, Chenchick, A A, Frangou, C, Gudkov, A V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823946/
https://www.ncbi.nlm.nih.gov/pubmed/26986512
http://dx.doi.org/10.1038/cddis.2016.45

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