From fighting depression to conquering tumors: a novel tricyclic thiazepine compound as a tubulin polymerization inhibitor

A novel tricyclic thiazepine derivative, 6-(p-tolyl)benzo[f] pyrido[2,3-b][1,4] thiazepine 11,11-dioxide (TBPT), exhibits potent inhibitory effects in two non-small-cell lung cancer cell lines, H460 and its drug-resistant variant, H460(TaxR), while exhibiting much less toxic effects on normal human...

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Detalles Bibliográficos
Autores principales: Mu, Y, Liu, Y, Xiang, J, Zhang, Q, Zhai, S, Russo, D P, Zhu, H, Bai, X, Yan, B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823954/
https://www.ncbi.nlm.nih.gov/pubmed/26986511
http://dx.doi.org/10.1038/cddis.2016.53

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