GW627368X inhibits proliferation and induces apoptosis in cervical cancer by interfering with EP4/EGFR interactive signaling

PGE2, the major product of cyclooxygenases implicated in carcinogenesis, is significantly upregulated in cervical cancer. PGE2 via prostanoid receptor EP4 stimulates proliferation and motility while inhibiting apoptosis and immune surveillance. It promotes angiogenesis by stimulating the production...

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Detalles Bibliográficos
Autores principales: Parida, S, Pal, I, Parekh, A, Thakur, B, Bharti, R, Das, S, Mandal, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823960/
https://www.ncbi.nlm.nih.gov/pubmed/27010855
http://dx.doi.org/10.1038/cddis.2016.61

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