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A new MCM modification cycle regulates DNA replication initiation

The MCM DNA helicase is a central regulatory target during genome replication. MCM is kept inactive during G1 and activated in S phase to initiate replication. During this transition, the only known chemical change on MCM is the gain of multi-site phosphorylation that promotes cofactor recruitment....

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Detalles Bibliográficos
Autores principales: Wei, Lei, Zhao, Xiaolan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823995/
https://www.ncbi.nlm.nih.gov/pubmed/26854664
http://dx.doi.org/10.1038/nsmb.3173