A novel role for CARM1 in promoting nonsense-mediated mRNA decay: potential implications for spinal muscular atrophy

Loss of ‘Survival of Motor Neurons’ (SMN) leads to spinal muscular atrophy (SMA), a disease characterized by degeneration of spinal cord alpha motor neurons, resulting in muscle weakness, paralysis and death during early childhood. SMN is required for assembly of the core splicing machinery, and spl...

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Detalles Bibliográficos
Autores principales: Sanchez, Gabriel, Bondy-Chorney, Emma, Laframboise, Janik, Paris, Geneviève, Didillon, Andréanne, Jasmin, Bernard J., Côté, Jocelyn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824080/
https://www.ncbi.nlm.nih.gov/pubmed/26656492
http://dx.doi.org/10.1093/nar/gkv1334

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