Non-canonical uracil processing in DNA gives rise to double-strand breaks and deletions: relevance to class switch recombination

During class switch recombination (CSR), antigen-stimulated B-cells rearrange their immunoglobulin constant heavy chain (C(H)) loci to generate antibodies with different effector functions. CSR is initiated by activation-induced deaminase (AID), which converts cytosines in switch (S) regions, repeti...

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Detalles Bibliográficos
Autores principales: Bregenhorn, Stephanie, Kallenberger, Lia, Artola-Borán, Mariela, Peña-Diaz, Javier, Jiricny, Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824095/
https://www.ncbi.nlm.nih.gov/pubmed/26743004
http://dx.doi.org/10.1093/nar/gkv1535

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