Cargando…

Chromosome-wide histone deacetylation by sirtuins prevents hyperactivation of DNA damage-induced signaling upon replicative stress

The Saccharomyces cerevisiae genome encodes five sirtuins (Sir2 and Hst1–4), which constitute a conserved family of NAD-dependent histone deacetylases. Cells lacking any individual sirtuin display mild growth and gene silencing defects. However, hst3Δ hst4Δ double mutants are exquisitely sensitive t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Simoneau, Antoine, Ricard, Étienne, Weber, Sandra, Hammond-Martel, Ian, Wong, Lai Hong, Sellam, Adnane, Giaever, Guri, Nislow, Corey, Raymond, Martine, Wurtele, Hugo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824096/ https://www.ncbi.nlm.nih.gov/pubmed/26748095 http://dx.doi.org/10.1093/nar/gkv1537

Ejemplares similares

Cockayne syndrome group B protein regulates fork restart, fork progression and MRE11-dependent fork degradation in BRCA1/2-deficient cells
por: Batenburg, Nicole L, et al.
Publicado: (2021)

SIRT1 deacetylates APE1 and regulates cellular base excision repair
por: Yamamori, Tohru, et al.
Publicado: (2010)

Human SIRT1 regulates DNA binding and stability of the Mcm10 DNA replication factor via deacetylation
por: Fatoba, Samuel T., et al.
Publicado: (2013)

DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining
por: Head, PamelaSara E, et al.
Publicado: (2023)

Histone H1 acetylation at lysine 85 regulates chromatin condensation and genome stability upon DNA damage
por: Li, Yinglu, et al.
Publicado: (2018)

Genetic vulnerabilities upon inhibition of DNA damage response
por: Wang, Chao, et al.
Publicado: (2021)

ATM induces MacroD2 nuclear export upon DNA damage
por: Golia, Barbara, et al.
Publicado: (2017)

Tumour suppressor ING1b maintains genomic stability upon replication stress
por: Wong, Ronald P. C., et al.
Publicado: (2011)

TRF2-mediated ORC recruitment underlies telomere stability upon DNA replication stress
por: Higa, Mitsunori, et al.
Publicado: (2021)

Replisome dysfunction upon inducible TIMELESS degradation synergizes with ATR inhibition to trigger replication catastrophe
por: Patel, Jinal A, et al.
Publicado: (2023)

Single-molecule visualization of human BLM helicase as it acts upon double- and single-stranded DNA substrates
por: Xue, Chaoyou, et al.
Publicado: (2019)

The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies
por: Mansour, Wael Y., et al.
Publicado: (2010)

RHAU helicase stabilizes G4 in its nucleotide-free state and destabilizes G4 upon ATP hydrolysis
por: You, Huijuan, et al.
Publicado: (2017)

Polyphosphate induces the proteolysis of ADP-bound fraction of initiator to inhibit DNA replication initiation upon stress in Escherichia coli
por: Gross, Marta H, et al.
Publicado: (2020)

An interplay between multiple sirtuins promotes completion of DNA replication in cells with short telomeres
por: Simoneau, Antoine, et al.
Publicado: (2018)

PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress
por: Illuzzi, Giuditta, et al.
Publicado: (2014)

GAA•TTC repeat expansion in human cells is mediated by mismatch repair complex MutLγ and depends upon the endonuclease domain in MLH3 isoform one
por: Halabi, Anasheh, et al.
Publicado: (2018)

Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage
por: Eccles, Laura J., et al.
Publicado: (2010)

Disruption of PARP1 function inhibits base excision repair of a sub-set of DNA lesions
por: Reynolds, Pamela, et al.
Publicado: (2015)

Processing of thymine glycol in a clustered DNA damage site: mutagenic or cytotoxic
por: Bellon, Sophie, et al.
Publicado: (2009)

Physical and functional interplay between PCNA DNA clamp and Mre11–Rad50 complex from the archaeon Pyrococcus furiosus
por: Hogrel, Gaëlle, et al.
Publicado: (2018)

Histone variant Htz1 promotes histone H3 acetylation to enhance nucleotide excision repair in Htz1 nucleosomes
por: Yu, Yachuan, et al.
Publicado: (2013)

Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity
por: Bader, Samuel B, et al.
Publicado: (2021)

A conserved lysine residue of plant Whirly proteins is necessary for higher order protein assembly and protection against DNA damage
por: Cappadocia, Laurent, et al.
Publicado: (2012)

Histone hypoacetylation is required to maintain late replication timing of constitutive heterochromatin
por: Casas-Delucchi, Corella S., et al.
Publicado: (2012)

Valproate inhibits MAP kinase signalling and cell cycle progression in S. cerevisiae
por: Desfossés-Baron, Kristelle, et al.
Publicado: (2016)

The histone variant H2A.Bbd is enriched at sites of DNA synthesis
por: Sansoni, Viola, et al.
Publicado: (2014)

Functional characterization and architecture of recombinant yeast SWR1 histone exchange complex
por: Lin, Chia-Liang, et al.
Publicado: (2017)

MutSβ and histone deacetylase complexes promote expansions of trinucleotide repeats in human cells
por: Gannon, Anne-Marie M., et al.
Publicado: (2012)

Poly(ADP-ribosyl)ation mediates early phase histone eviction at DNA lesions
por: Yang, Guang, et al.
Publicado: (2020)

Structural and functional determinants of the archaeal 8-oxoguanine-DNA glycosylase AGOG for DNA damage recognition and processing
por: Franck, Coste, et al.
Publicado: (2022)

Histone H2B mono-ubiquitylation maintains genomic integrity at stalled replication forks
por: Northam, Matthew R., et al.
Publicado: (2016)

USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair
por: Ting, Xia, et al.
Publicado: (2019)

Histone dosage regulates DNA damage sensitivity in a checkpoint-independent manner by the homologous recombination pathway
por: Liang, Dun, et al.
Publicado: (2012)

ESA1 regulates meiotic chromosome axis and crossover frequency via acetylating histone H4
por: Wang, Ying, et al.
Publicado: (2021)

53BP1-ACLY-SLBP-coordinated activation of replication-dependent histone biogenesis maintains genomic integrity
por: Wu, TingTing, et al.
Publicado: (2022)

Bre1-dependent H2B ubiquitination promotes homologous recombination by stimulating histone eviction at DNA breaks
por: Zheng, Sihao, et al.
Publicado: (2018)

CAF-1 deposits newly synthesized histones during DNA replication using distinct mechanisms on the leading and lagging strands
por: Rouillon, Clément, et al.
Publicado: (2023)

Histone H3 Lys79 methylation is required for efficient nucleotide excision repair in a silenced locus of Saccharomyces cerevisiae
por: Chaudhuri, Shubho, et al.
Publicado: (2009)

Histone H3 lysine 36 methyltransferase mobilizes NER factors to regulate tolerance against alkylation damage in fission yeast
por: Lim, Kim Kiat, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_54vlr24cfjvo83e65fsdedsicj