Enrichment of Cdk1-cyclins at DNA double-strand breaks stimulates Fun30 phosphorylation and DNA end resection

DNA double-strand breaks (DSBs) are one of the most cytotoxic types of DNA lesion challenging genome integrity. The activity of cyclin-dependent kinase Cdk1 is essential for DSB repair by homologous recombination and for DNA damage signaling. Here we identify the Fun30 chromatin remodeler as a new t...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Xuefeng, Niu, Hengyao, Yu, Yang, Wang, Jingjing, Zhu, Shuangyi, Zhou, Jianjie, Papusha, Alma, Cui, Dandan, Pan, Xuewen, Kwon, Youngho, Sung, Patrick, Ira, Grzegorz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824098/
https://www.ncbi.nlm.nih.gov/pubmed/26801641
http://dx.doi.org/10.1093/nar/gkv1544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824098/
https://www.ncbi.nlm.nih.gov/pubmed/26801641
http://dx.doi.org/10.1093/nar/gkv1544

Ejemplares similares