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Overhang polarity of chromosomal double-strand breaks impacts kinetics and fidelity of yeast non-homologous end joining

Non-homologous end joining (NHEJ) is the main repair pathway for DNA double-strand breaks (DSBs) in cells with limited 5′ resection. To better understand how overhang polarity of chromosomal DSBs affects NHEJ, we made site-specific 5′-overhanging DSBs (5′ DSBs) in yeast using an optimized zinc finge...

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Detalles Bibliográficos
Autores principales:	Liang, Zhuobin, Sunder, Sham, Nallasivam, Sivakumar, Wilson, Thomas E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824102/ https://www.ncbi.nlm.nih.gov/pubmed/26773053 http://dx.doi.org/10.1093/nar/gkw013

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