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Immunodetection of human topoisomerase I-DNA covalent complexes

A number of established and investigational anticancer drugs slow the religation step of DNA topoisomerase I (topo I). These agents induce cytotoxicity by stabilizing topo I-DNA covalent complexes, which in turn interact with advancing replication forks or transcription complexes to generate lethal...

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Detalles Bibliográficos
Autores principales:	Patel, Anand G., Flatten, Karen S., Peterson, Kevin L., Beito, Thomas G., Schneider, Paula A., Perkins, Angela L., Harki, Daniel A., Kaufmann, Scott H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824114/ https://www.ncbi.nlm.nih.gov/pubmed/26917015 http://dx.doi.org/10.1093/nar/gkw109

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