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Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells

The accuracy of replicating the genetic code is fundamental. DNA repair mechanisms protect the fidelity of the genome ensuring a low error rate between generations. This sustains the similarity of individuals whilst providing a repertoire of variants for evolution. The mutation rate in the human gen...

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Detalles Bibliográficos
Autores principales:	Rouhani, Foad J., Nik-Zainal, Serena, Wuster, Arthur, Li, Yilong, Conte, Nathalie, Koike-Yusa, Hiroko, Kumasaka, Natsuhiko, Vallier, Ludovic, Yusa, Kosuke, Bradley, Allan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824386/ https://www.ncbi.nlm.nih.gov/pubmed/27054363 http://dx.doi.org/10.1371/journal.pgen.1005932

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