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The HSV-1 Latency-Associated Transcript Functions to Repress Latent Phase Lytic Gene Expression and Suppress Virus Reactivation from Latently Infected Neurons

Herpes simplex virus 1 (HSV-1) establishes life-long latent infection within sensory neurons, during which viral lytic gene expression is silenced. The only highly expressed viral gene product during latent infection is the latency-associated transcript (LAT), a non-protein coding RNA that has been...

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Detalles Bibliográficos
Autores principales:	Nicoll, Michael P., Hann, William, Shivkumar, Maitreyi, Harman, Laura E. R., Connor, Viv, Coleman, Heather M., Proença, João T., Efstathiou, Stacey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824392/ https://www.ncbi.nlm.nih.gov/pubmed/27055281 http://dx.doi.org/10.1371/journal.ppat.1005539

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