Cargando…

Hyaluronan Inhibits Tlr-4-Dependent RANKL Expression in Human Rheumatoid Arthritis Synovial Fibroblasts

The Toll-like receptor (TLR) signaling pathway is activated in synovial fibroblast cells in patients with rheumatoid arthritis (RA). The receptor activator of nuclear factor-κB (RANK) and its ligand, RANKL, are key molecules involved in the differentiation of osteoclasts and joint destruction in RA....

Descripción completa

Detalles Bibliográficos
Autores principales:	Watanabe, Tatsuo, Takahashi, Nobunori, Hirabara, Shinya, Ishiguro, Naoki, Kojima, Toshihisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824426/ https://www.ncbi.nlm.nih.gov/pubmed/27054952 http://dx.doi.org/10.1371/journal.pone.0153142

Ejemplares similares

Hyaluronan Oligosaccharides Induce MMP-1 and -3 via Transcriptional Activation of NF-κB and p38 MAPK in Rheumatoid Synovial Fibroblasts
por: Hanabayashi, Masahiro, et al.
Publicado: (2016)

Hyaluronan promotes TRPV4-induced chondrogenesis in ATDC5 cells
por: Ogawa, Yoshikazu, et al.
Publicado: (2019)

Predictors of denosumab efficacy in treating osteoporosis in patients with rheumatoid arthritis: a Japanese multicenter study
por: Hattori, Kyosuke, et al.
Publicado: (2019)

Clinical efficacy of abatacept, tocilizumab, and etanercept in Japanese rheumatoid arthritis patients with inadequate response to anti-TNF monoclonal antibodies
por: Hirabara, Shinya, et al.
Publicado: (2014)

Relationship between rheumatoid arthritis and locomotive syndrome: validation of the 25-question Geriatric Locomotive Function Scale in patients with rheumatoid arthritis
por: Sobue, Yasumori, et al.
Publicado: (2019)

Hyaluronan suppresses enhanced cathepsin K expression via activation of NF-κB with mechanical stress loading in a human chondrocytic HCS-2/8 cells
por: Suzuki, Mochihito, et al.
Publicado: (2020)

Changes in perioperative C-reactive protein levels in patients with rheumatoid arthritis undergoing total knee arthroplasty in the biologic era
por: Kishimoto, Kenji, et al.
Publicado: (2022)

Computed tomography evaluation of the periacetabular gap of a porous tantalum acetabular component
por: Asai, Shuji, et al.
Publicado: (2019)

Clinical efficacy of abatacept compared to adalimumab and tocilizumab in rheumatoid arthritis patients with high disease activity
por: Takahashi, Nobunori, et al.
Publicado: (2013)

Activation of Synovial Fibroblasts in Rheumatoid Arthritis
por: Gay, Steffen, et al.
Publicado: (2000)

Association of autophagy to the phenotypic transformation of synovial fibroblasts in rheumatoid arthritis
por: Kondo, Naoki
Publicado: (2022)

OPG and RANKL in serum and synovial fluids of patients with rheumatoid arthritis, osteoarthritis and spondylarthropathy
por: Krystufkova, O, et al.
Publicado: (2003)

Cells of the synovium in rheumatoid arthritis. Synovial fibroblasts
por: Müller-Ladner, Ulf, et al.
Publicado: (2007)

Evidence for synovial fibroblasts spreading rheumatoid arthritis
por: Müller-Ladner, Ulf, et al.
Publicado: (2012)

Multiomics landscape of synovial fibroblasts in rheumatoid arthritis
por: Tsuchiya, Haruka, et al.
Publicado: (2021)

Drivers of heterogeneity in synovial fibroblasts in rheumatoid arthritis
por: Smith, Melanie H., et al.
Publicado: (2023)

Predictors for clinical effectiveness of baricitinib in rheumatoid arthritis patients in routine clinical practice: data from a Japanese multicenter registry
por: Takahashi, Nobunori, et al.
Publicado: (2020)

Fragmented hyaluronan has no alarmin function assessed in arthritis synovial fibroblast and chondrocyte cultures
por: Olsson, Mia, et al.
Publicado: (2018)

Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages
por: Matsumoto, Takuya, et al.
Publicado: (2016)

Characterization of hyaluronan-coated extracellular vesicles in synovial fluid of patients with osteoarthritis and rheumatoid arthritis
por: Mustonen, Anne-Mari, et al.
Publicado: (2021)

Fibroblast biology: Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis
por: Pap, Thomas, et al.
Publicado: (2000)

Targeting Activated Synovial Fibroblasts in Rheumatoid Arthritis by Peficitinib
por: Diller, Magnus, et al.
Publicado: (2019)

Molecular profile of synovial fibroblasts in rheumatoid arthritis depends on the stage of proliferation
por: Masuda, Kimio, et al.
Publicado: (2002)

Differential gene expression of proliferating synovial fibroblasts in rheumatoid arthritis
por: Masuda, KM, et al.
Publicado: (2002)

Transcriptional response to hypoxia of normal and rheumatoid arthritis synovial fibroblasts
por: Del Rey, M J, et al.
Publicado: (2010)

The epigenome of synovial fibroblasts: an underestimated therapeutic target in rheumatoid arthritis
por: Frank-Bertoncelj, Mojca, et al.
Publicado: (2014)

Profiling drugs for rheumatoid arthritis that inhibit synovial fibroblast activation
por: Jones, Douglas S., et al.
Publicado: (2016)

Marker Genes Change of Synovial Fibroblasts in Rheumatoid Arthritis Patients
por: Liao, Lifen, et al.
Publicado: (2021)

Fibroblast biology: Synovial fibroblasts in rheumatoid arthritis - leading role or chorus line?
por: Kontoyiannis, Dimitris, et al.
Publicado: (2000)

The inhibitor of differentiation-2 promotes synovial fibroblast-dependent osteoclastogenesis in rheumatoid arthritis
por: Kurowska-Stolarska, M, et al.
Publicado: (2005)

Effects of hyaluronan treatment on lipopolysaccharide-challenged fibroblast-like synovial cells
por: Santangelo, Kelly S, et al.
Publicado: (2007)

Role of synovial fibroblast subsets across synovial pathotypes in rheumatoid arthritis: a deconvolution analysis
por: Micheroli, Raphael, et al.
Publicado: (2022)

Methotrexate Alters the Expression of microRNA in Fibroblast-like Synovial Cells in Rheumatoid Arthritis
por: Iwamoto, Naoki, et al.
Publicado: (2021)

Locomotive syndrome in rheumatoid arthritis patients during the COVID-19 pandemic
por: Sobue, Yasumori, et al.
Publicado: (2022)

Crosstalk between synovial fibroblasts and T lymphocytes in rheumatoid arthritis: effect of methotrexate
por: Miranda, E, et al.
Publicado: (2003)

Cigarette smoke downregulates HDAC2 in rheumatoid arthritis synovial fibroblasts
por: Engler, Anna, et al.
Publicado: (2012)

New insights into integrin signalling: implications for rheumatoid arthritis synovial fibroblasts
por: Pap, Thomas
Publicado: (2003)

Optimized “In Vitro” Culture Conditions for Human Rheumatoid Arthritis Synovial Fibroblasts
por: Casnici, Claudia, et al.
Publicado: (2014)

MicroRNAs interfere with DNA methylation in rheumatoid arthritis synovial fibroblasts
por: Gaur, Niharika, et al.
Publicado: (2016)

Cannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblasts
por: Lowin, Torsten, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_2jfctui8cl1n82jrst3p4ubbem