Substrate complexes of human dipeptidyl peptidase III reveal the mechanism of enzyme inhibition

Human dipeptidyl-peptidase III (hDPP III) is a zinc-dependent hydrolase cleaving dipeptides off the N-termini of various bioactive peptides. Thus, the enzyme is likely involved in a number of physiological processes such as nociception and is also implicated in several forms of cancer. We present hi...

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Detalles Bibliográficos
Autores principales: Kumar, Prashant, Reithofer, Viktoria, Reisinger, Manuel, Wallner, Silvia, Pavkov-Keller, Tea, Macheroux, Peter, Gruber, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824452/
https://www.ncbi.nlm.nih.gov/pubmed/27025154
http://dx.doi.org/10.1038/srep23787

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824452/
https://www.ncbi.nlm.nih.gov/pubmed/27025154
http://dx.doi.org/10.1038/srep23787

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