Covalent Bonding of Pyrrolobenzodiazepines (PBDs) to Terminal Guanine Residues within Duplex and Hairpin DNA Fragments

Pyrrolobenzodiazepines (PBDs) are covalent-binding DNA-interactive agents with growing importance as payloads in Antibody Drug Conjugates (ADCs). Until now, PBDs were thought to covalently bond to C2-NH(2) groups of guanines in the DNA-minor groove across a three-base-pair recognition sequence. Usin...

Descripción completa

Detalles Bibliográficos
Autores principales: Mantaj, Julia, Jackson, Paul J. M., Karu, Kersti, Rahman, Khondaker M., Thurston, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824457/
https://www.ncbi.nlm.nih.gov/pubmed/27055050
http://dx.doi.org/10.1371/journal.pone.0152303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824457/
https://www.ncbi.nlm.nih.gov/pubmed/27055050
http://dx.doi.org/10.1371/journal.pone.0152303

Ejemplares similares