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Leptin Production by Encapsulated Adipocytes Increases Brown Fat, Decreases Resistin, and Improves Glucose Intolerance in Obese Mice
The neuroendocrine effects of leptin on metabolism hold promise to be translated into a complementary therapy to traditional insulin therapy for diabetes and obesity. However, injections of leptin can provoke inflammation. We tested the effects of leptin, produced in the physiological adipocyte loca...
Autores principales: | DiSilvestro, David J., Melgar-Bermudez, Emiliano, Yasmeen, Rumana, Fadda, Paolo, Lee, L. James, Kalyanasundaram, Anuradha, Gilor, Chen L., Ziouzenkova, Ouliana |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824514/ https://www.ncbi.nlm.nih.gov/pubmed/27055280 http://dx.doi.org/10.1371/journal.pone.0153198 |
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