Enhanced lysis by bispecific oncolytic measles viruses simultaneously using HER2/neu or EpCAM as target receptors

To target oncolytic measles viruses (MV) to tumors, we exploit the binding specificity of designed ankyrin repeat proteins (DARPins). These DARPin-MVs have high tumor selectivity while maintaining excellent oncolytic potency. Stability, small size, and efficacy of DARPins allowed the generation of M...

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Detalles Bibliográficos
Autores principales: Hanauer, Jan RH, Gottschlich, Lisa, Riehl, Dennis, Rusch, Tillmann, Koch, Vivian, Friedrich, Katrin, Hutzler, Stefan, Prüfer, Steffen, Friedel, Thorsten, Hanschmann, Kay-Martin, Münch, Robert C, Jost, Christian, Plückthun, Andreas, Cichutek, Klaus, Buchholz, Christian J, Mühlebach, Michael D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824561/
https://www.ncbi.nlm.nih.gov/pubmed/27119117
http://dx.doi.org/10.1038/mto.2016.3

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