Cargando…

Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis

Autophagy is triggered in vascular smooth muscle cells (VSMCs) of diseased arterial vessels. However, the role of VSMC autophagy in cardiovascular disease is poorly understood. Therefore, we investigated the effect of defective autophagy on VSMC survival and phenotype and its significance in the dev...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grootaert, Mandy OJ, da Costa Martins, Paula A, Bitsch, Nicole, Pintelon, Isabel, De Meyer, Guido RY, Martinet, Wim, Schrijvers, Dorien M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2015
Materias:	Basic Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824610/ https://www.ncbi.nlm.nih.gov/pubmed/26391655 http://dx.doi.org/10.1080/15548627.2015.1096485

Ejemplares similares

Defective Autophagy in Atherosclerosis: To Die or to Senesce?
por: Grootaert, Mandy O. J., et al.
Publicado: (2018)

Partial Inhibition of Glycolysis Reduces Atherogenesis Independent of Intraplaque Neovascularization in Mice
por: Perrotta, Paola, et al.
Publicado: (2020)

SIRT6 Protects Smooth Muscle Cells From Senescence and Reduces Atherosclerosis
por: Grootaert, Mandy O.J., et al.
Publicado: (2020)

Defective Autophagy in Vascular Smooth Muscle Cells Alters Vascular Reactivity of the Mouse Femoral Artery
por: De Munck, Dorien G., et al.
Publicado: (2020)

Caspase-3 Deletion Promotes Necrosis in Atherosclerotic Plaques of ApoE Knockout Mice
por: Grootaert, Mandy O. J., et al.
Publicado: (2016)

Comparison of Apoptosis Detection Markers Combined with Macrophage Immunostaining to Study Phagocytosis of Apoptotic Cells in Situ
por: Schrijvers, Dorien M., et al.
Publicado: (2007)

S-phase kinase-associated protein-2 (Skp2) promotes vascular smooth muscle cell proliferation and neointima formation in vivo
por: Wu, Yih-Jer, et al.
Publicado: (2009)

SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis
por: Stein, Sokrates, et al.
Publicado: (2010)

Elastin fragmentation in atherosclerotic mice leads to intraplaque neovascularization, plaque rupture, myocardial infarction, stroke, and sudden death
por: Van der Donckt, Carole, et al.
Publicado: (2015)

Parent artery-initiated and stent-mediated neointima formation in a rat saccular side wall model
por: Wanderer, Stefan, et al.
Publicado: (2022)

Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α–Dependent Senescence-Associated Secretory Phenotype
por: Gardner, Sarah E., et al.
Publicado: (2015)

circ-Sirt1 Decelerates Senescence by Inhibiting p53 Activation in Vascular Smooth Muscle Cells, Ameliorating Neointima Formation
por: Kong, Peng, et al.
Publicado: (2021)

Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation
por: Winnik, Stephan, et al.
Publicado: (2011)

Vascular Smooth Muscle Cell Plasticity and Autophagy in Dissecting Aortic Aneurysms
por: Clément, Marc, et al.
Publicado: (2019)

Aortic Stiffness in L-NAME Treated C57Bl/6 Mice Displays a Shift From Early Endothelial Dysfunction to Late-Term Vascular Smooth Muscle Cell Dysfunction
por: De Moudt, Sofie, et al.
Publicado: (2022)

Single-cell analysis challenges the connection between autophagy and senescence induced by DNA damage
por: Filippi-Chiela, Eduardo Cremonese, et al.
Publicado: (2015)

Bilirubin Inhibits Neointima Formation and Vascular Smooth Muscle Cell Proliferation and Migration
por: Peyton, Kelly J., et al.
Publicado: (2012)

The Impact of RIPK1 Kinase Inhibition on Atherogenesis: A Genetic and a Pharmacological Approach
por: Puylaert, Pauline, et al.
Publicado: (2022)

Acetylsalicylic Acid Reduces Passive Aortic Wall Stiffness and Cardiovascular Remodelling in a Mouse Model of Advanced Atherosclerosis
por: Roth, Lynn, et al.
Publicado: (2021)

Transcript and Protein Analysis Reveals Better Survival Skills of Monocyte-Derived Dendritic Cells Compared to Monocytes during Oxidative Stress
por: Van Brussel, Ilse, et al.
Publicado: (2012)

Endothelial cell repopulation after stenting determines in-stent neointima formation: effects of bare-metal vs. drug-eluting stents and genetic endothelial cell modification
por: Douglas, Gillian, et al.
Publicado: (2013)

Inhibition of STAT3 signaling prevents vascular smooth muscle cell proliferation and neointima formation
por: Daniel, Jan-Marcus, et al.
Publicado: (2012)

Gastrodin inhibits cell proliferation in vascular smooth muscle cells and attenuates neointima formation in vivo
por: ZHU, LIHUA, et al.
Publicado: (2012)

Genistein suppresses leptin‐induced proliferation and migration of vascular smooth muscle cells and neointima formation
por: Tsai, Yung‐Chieh, et al.
Publicado: (2016)

Empagliflozin prevents neointima formation by impairing smooth muscle cell proliferation and accelerating endothelial regeneration
por: Dutzmann, Jochen, et al.
Publicado: (2022)

Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury
por: Uryga, Anna K., et al.
Publicado: (2021)

Exosomes and Atherogenesis
por: Lin, Bingbing, et al.
Publicado: (2021)

The Role of Autophagy in Critical Illness-induced Liver Damage
por: Thiessen, Steven E., et al.
Publicado: (2017)

Previously differentiated medial vascular smooth muscle cells contribute to neointima formation following vascular injury
por: Herring, Brian Paul, et al.
Publicado: (2014)

Interferon Regulatory Factor 7 Protects Against Vascular Smooth Muscle Cell Proliferation and Neointima Formation
por: Huang, Ling, et al.
Publicado: (2014)

Xanthohumol Blocks Proliferation and Migration of Vascular Smooth Muscle Cells in Vitro and Reduces Neointima Formation in Vivo
por: Liu, Rongxia, et al.
Publicado: (2017)

Role of FOXM1 in vascular smooth muscle cell survival and neointima formation following vascular injury
por: Franco, Sarah, et al.
Publicado: (2020)

Mediator Med23 deficiency in smooth muscle cells prevents neointima formation after arterial injury
por: Sun, Xiaoli, et al.
Publicado: (2021)

USP10 exacerbates neointima formation by stabilizing Skp2 protein in vascular smooth muscle cells
por: Xia, Xiaohong, et al.
Publicado: (2021)

miRNA-21 is dysregulated in response to vein grafting in multiple models and genetic ablation in mice attenuates neointima formation
por: McDonald, Robert A., et al.
Publicado: (2013)

Long-Term Depletion of Conventional Dendritic Cells Cannot Be Maintained in an Atherosclerotic Zbtb46-DTR Mouse Model
por: Rombouts, Miche, et al.
Publicado: (2017)

Contribution of transient and sustained calcium influx, and sensitization to depolarization-induced contractions of the intact mouse aorta
por: Fransen, Paul, et al.
Publicado: (2012)

Smooth Muscle–Selective Inhibition of Nuclear Factor‐κB Attenuates Smooth Muscle Phenotypic Switching and Neointima Formation Following Vascular Injury
por: Yoshida, Tadashi, et al.
Publicado: (2013)

Single-Cell RNA-Seq Reveals a Population of Smooth Muscle Cells Responsible for Atherogenesis
por: Shi, Xiaofeng, et al.
Publicado: (2022)

MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells
por: Filippov, Sergey, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_i0ll8444phrl44pveftkkid0ph