The role of ANGPTL3 in controlling lipoprotein metabolism

Angiopoietin-like protein 3 (ANGPTL3) is a secretory protein regulating plasma lipid levels via affecting lipoprotein lipase- and endothelial lipase-mediated hydrolysis of triglycerides and phospholipids. ANGPTL3-deficiency due to loss-of-function mutations in the ANGPTL3 gene causes familial combin...

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Detalles Bibliográficos
Autores principales: Tikka, Anna, Jauhiainen, Matti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824806/
https://www.ncbi.nlm.nih.gov/pubmed/26754661
http://dx.doi.org/10.1007/s12020-015-0838-9
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author Tikka, Anna
Jauhiainen, Matti
author_facet Tikka, Anna
Jauhiainen, Matti
author_sort Tikka, Anna
collection PubMed
description Angiopoietin-like protein 3 (ANGPTL3) is a secretory protein regulating plasma lipid levels via affecting lipoprotein lipase- and endothelial lipase-mediated hydrolysis of triglycerides and phospholipids. ANGPTL3-deficiency due to loss-of-function mutations in the ANGPTL3 gene causes familial combined hypobetalipoproteinemia (FHBL2, OMIM # 605019), a phenotype characterized by low concentration of all major lipoprotein classes in circulation. ANGPTL3 is therefore a potential therapeutic target to treat combined hyperlipidemia, a major risk factor for atherosclerotic coronary heart disease. This review focuses on the mechanisms behind ANGPTL3-deficiency induced FHBL2.
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spelling pubmed-48248062016-04-20 The role of ANGPTL3 in controlling lipoprotein metabolism Tikka, Anna Jauhiainen, Matti Endocrine Review Angiopoietin-like protein 3 (ANGPTL3) is a secretory protein regulating plasma lipid levels via affecting lipoprotein lipase- and endothelial lipase-mediated hydrolysis of triglycerides and phospholipids. ANGPTL3-deficiency due to loss-of-function mutations in the ANGPTL3 gene causes familial combined hypobetalipoproteinemia (FHBL2, OMIM # 605019), a phenotype characterized by low concentration of all major lipoprotein classes in circulation. ANGPTL3 is therefore a potential therapeutic target to treat combined hyperlipidemia, a major risk factor for atherosclerotic coronary heart disease. This review focuses on the mechanisms behind ANGPTL3-deficiency induced FHBL2. Springer US 2016-01-11 2016 /pmc/articles/PMC4824806/ /pubmed/26754661 http://dx.doi.org/10.1007/s12020-015-0838-9 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Tikka, Anna
Jauhiainen, Matti
The role of ANGPTL3 in controlling lipoprotein metabolism
title The role of ANGPTL3 in controlling lipoprotein metabolism
title_full The role of ANGPTL3 in controlling lipoprotein metabolism
title_fullStr The role of ANGPTL3 in controlling lipoprotein metabolism
title_full_unstemmed The role of ANGPTL3 in controlling lipoprotein metabolism
title_short The role of ANGPTL3 in controlling lipoprotein metabolism
title_sort role of angptl3 in controlling lipoprotein metabolism
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824806/
https://www.ncbi.nlm.nih.gov/pubmed/26754661
http://dx.doi.org/10.1007/s12020-015-0838-9
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