Predictions of Cleavability of Calpain Proteolysis by Quantitative Structure-Activity Relationship Analysis Using Newly Determined Cleavage Sites and Catalytic Efficiencies of an Oligopeptide Array

Calpains are intracellular Ca(2+)-regulated cysteine proteases that are essential for various cellular functions. Mammalian conventional calpains (calpain-1 and calpain-2) modulate the structure and function of their substrates by limited proteolysis. Thus, it is critically important to determine th...

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Detalles Bibliográficos
Autores principales: Shinkai-Ouchi, Fumiko, Koyama, Suguru, Ono, Yasuko, Hata, Shoji, Ojima, Koichi, Shindo, Mayumi, duVerle, David, Ueno, Mika, Kitamura, Fujiko, Doi, Naoko, Takigawa, Ichigaku, Mamitsuka, Hiroshi, Sorimachi, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824854/
https://www.ncbi.nlm.nih.gov/pubmed/26796116
http://dx.doi.org/10.1074/mcp.M115.053413

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