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Pine polyphenols from Pinus koraiensis prevent injuries induced by gamma radiation in mice

Pine polyphenols (PPs) are bioactive dietary constituents that enhance health and help prevent diseases through antioxidants. Antioxidants reduce the level of oxidative damages caused by ionizing radiation (IR). The main purpose of this paper is to study the protective effect of PPs on peripheral bl...

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Detalles Bibliográficos
Autores principales: Li, Hui, Wang, Zhenyu, Xu, Yier, Sun, Guicai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824883/
https://www.ncbi.nlm.nih.gov/pubmed/27069807
http://dx.doi.org/10.7717/peerj.1870
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author Li, Hui
Wang, Zhenyu
Xu, Yier
Sun, Guicai
author_facet Li, Hui
Wang, Zhenyu
Xu, Yier
Sun, Guicai
author_sort Li, Hui
collection PubMed
description Pine polyphenols (PPs) are bioactive dietary constituents that enhance health and help prevent diseases through antioxidants. Antioxidants reduce the level of oxidative damages caused by ionizing radiation (IR). The main purpose of this paper is to study the protective effect of PPs on peripheral blood, liver and spleen injuries in mice induced by IR. ICR (Institute of Cancer Research) male mice were administered orally with PPs (200 mg/kg b.wt.) once daily for 14 consecutive days prior to 7 Gy γ-radiations. PPs showed strong antioxidant activities. PPs significantly increased white blood cells, red blood cells and platelets counts. PPs also significantly reduced lipid peroxidation and increased the activities of superoxide dismutase, catalase and glutathione peroxidases, and the level of glutathione. PPs reduced the spleen morphologic injury. In addition, PPs inhibited mitochondria-dependent apoptosis pathways in splenocytes induced by IR. These results indicate that PPs are radioprotective promising reagents.
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spelling pubmed-48248832016-04-11 Pine polyphenols from Pinus koraiensis prevent injuries induced by gamma radiation in mice Li, Hui Wang, Zhenyu Xu, Yier Sun, Guicai PeerJ Biochemistry Pine polyphenols (PPs) are bioactive dietary constituents that enhance health and help prevent diseases through antioxidants. Antioxidants reduce the level of oxidative damages caused by ionizing radiation (IR). The main purpose of this paper is to study the protective effect of PPs on peripheral blood, liver and spleen injuries in mice induced by IR. ICR (Institute of Cancer Research) male mice were administered orally with PPs (200 mg/kg b.wt.) once daily for 14 consecutive days prior to 7 Gy γ-radiations. PPs showed strong antioxidant activities. PPs significantly increased white blood cells, red blood cells and platelets counts. PPs also significantly reduced lipid peroxidation and increased the activities of superoxide dismutase, catalase and glutathione peroxidases, and the level of glutathione. PPs reduced the spleen morphologic injury. In addition, PPs inhibited mitochondria-dependent apoptosis pathways in splenocytes induced by IR. These results indicate that PPs are radioprotective promising reagents. PeerJ Inc. 2016-04-05 /pmc/articles/PMC4824883/ /pubmed/27069807 http://dx.doi.org/10.7717/peerj.1870 Text en ©2016 Li et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Biochemistry
Li, Hui
Wang, Zhenyu
Xu, Yier
Sun, Guicai
Pine polyphenols from Pinus koraiensis prevent injuries induced by gamma radiation in mice
title Pine polyphenols from Pinus koraiensis prevent injuries induced by gamma radiation in mice
title_full Pine polyphenols from Pinus koraiensis prevent injuries induced by gamma radiation in mice
title_fullStr Pine polyphenols from Pinus koraiensis prevent injuries induced by gamma radiation in mice
title_full_unstemmed Pine polyphenols from Pinus koraiensis prevent injuries induced by gamma radiation in mice
title_short Pine polyphenols from Pinus koraiensis prevent injuries induced by gamma radiation in mice
title_sort pine polyphenols from pinus koraiensis prevent injuries induced by gamma radiation in mice
topic Biochemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824883/
https://www.ncbi.nlm.nih.gov/pubmed/27069807
http://dx.doi.org/10.7717/peerj.1870
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