Heterotrimeric G Protein-coupled Receptor Signaling in Yeast Mating Pheromone Response

The DNAs encoding the receptors that respond to the peptide mating pheromones of the budding yeast Saccharomyces cerevisiae were isolated in 1985, and were the very first genes for agonist-binding heterotrimeric G protein-coupled receptors (GPCRs) to be cloned in any organism. Now, over 30 years lat...

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Autores principales: Alvaro, Christopher G., Thorner, Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Minireviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824985/
https://www.ncbi.nlm.nih.gov/pubmed/26907689
http://dx.doi.org/10.1074/jbc.R116.714980
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author Alvaro, Christopher G.
Thorner, Jeremy
author_facet Alvaro, Christopher G.
Thorner, Jeremy
author_sort Alvaro, Christopher G.
collection PubMed
description The DNAs encoding the receptors that respond to the peptide mating pheromones of the budding yeast Saccharomyces cerevisiae were isolated in 1985, and were the very first genes for agonist-binding heterotrimeric G protein-coupled receptors (GPCRs) to be cloned in any organism. Now, over 30 years later, this yeast and its receptors continue to provide a pathfinding experimental paradigm for investigating GPCR-initiated signaling and its regulation, as described in this retrospective overview.
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spelling pubmed-48249852016-04-21 Heterotrimeric G Protein-coupled Receptor Signaling in Yeast Mating Pheromone Response Alvaro, Christopher G. Thorner, Jeremy J Biol Chem Minireviews The DNAs encoding the receptors that respond to the peptide mating pheromones of the budding yeast Saccharomyces cerevisiae were isolated in 1985, and were the very first genes for agonist-binding heterotrimeric G protein-coupled receptors (GPCRs) to be cloned in any organism. Now, over 30 years later, this yeast and its receptors continue to provide a pathfinding experimental paradigm for investigating GPCR-initiated signaling and its regulation, as described in this retrospective overview. American Society for Biochemistry and Molecular Biology 2016-04-08 2016-02-23 /pmc/articles/PMC4824985/ /pubmed/26907689 http://dx.doi.org/10.1074/jbc.R116.714980 Text en © 2016 by The American Society for Biochemistry and Molecular Biology, Inc. Author's Choice—Final version free via Creative Commons CC-BY license (http://creativecommons.org/licenses/by/4.0) .
spellingShingle Minireviews
Alvaro, Christopher G.
Thorner, Jeremy
Heterotrimeric G Protein-coupled Receptor Signaling in Yeast Mating Pheromone Response
title Heterotrimeric G Protein-coupled Receptor Signaling in Yeast Mating Pheromone Response
title_full Heterotrimeric G Protein-coupled Receptor Signaling in Yeast Mating Pheromone Response
title_fullStr Heterotrimeric G Protein-coupled Receptor Signaling in Yeast Mating Pheromone Response
title_full_unstemmed Heterotrimeric G Protein-coupled Receptor Signaling in Yeast Mating Pheromone Response
title_short Heterotrimeric G Protein-coupled Receptor Signaling in Yeast Mating Pheromone Response
title_sort heterotrimeric g protein-coupled receptor signaling in yeast mating pheromone response
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824985/
https://www.ncbi.nlm.nih.gov/pubmed/26907689
http://dx.doi.org/10.1074/jbc.R116.714980
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