Co-immunoprecipitation with Tau Isoform-specific Antibodies Reveals Distinct Protein Interactions and Highlights a Putative Role for 2N Tau in Disease

Alternative splicing generates multiple isoforms of the microtubule-associated protein Tau, but little is known about their specific function. In the adult mouse brain, three Tau isoforms are expressed that contain either 0, 1, or 2 N-terminal inserts (0N, 1N, and 2N). We generated Tau isoform-speci...

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Detalles Bibliográficos
Autores principales: Liu, Chang, Song, Xiaomin, Nisbet, Rebecca, Götz, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825019/
https://www.ncbi.nlm.nih.gov/pubmed/26861879
http://dx.doi.org/10.1074/jbc.M115.641902

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825019/
https://www.ncbi.nlm.nih.gov/pubmed/26861879
http://dx.doi.org/10.1074/jbc.M115.641902

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