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DNA and Protein Requirements for Substrate Conformational Changes Necessary for Human Flap Endonuclease-1-catalyzed Reaction

Human flap endonuclease-1 (hFEN1) catalyzes the essential removal of single-stranded flaps arising at DNA junctions during replication and repair processes. hFEN1 biological function must be precisely controlled, and consequently, the protein relies on a combination of protein and substrate conforma...

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Detalles Bibliográficos
Autores principales:	Algasaier, Sana I., Exell, Jack C., Bennet, Ian A., Thompson, Mark J., Gotham, Victoria J. B., Shaw, Steven J., Craggs, Timothy D., Finger, L. David, Grasby, Jane A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2016
Materias:	DNA and Chromosomes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825025/ https://www.ncbi.nlm.nih.gov/pubmed/26884332 http://dx.doi.org/10.1074/jbc.M115.698993

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