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Bayesian evidence synthesis to estimate HIV prevalence in men who have sex with men in Poland at the end of 2009

HIV spread in men who have sex with men (MSM) is an increasing problem in Poland. Despite the existence of a surveillance system, there is no direct evidence to allow estimation of HIV prevalence and the proportion undiagnosed in MSM. We extracted data on HIV and the MSM population in Poland, includ...

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Autores principales: ROSINSKA, M., GWIAZDA, P., DE ANGELIS, D., PRESANIS, A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825105/
https://www.ncbi.nlm.nih.gov/pubmed/26542091
http://dx.doi.org/10.1017/S0950268815002538
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author ROSINSKA, M.
GWIAZDA, P.
DE ANGELIS, D.
PRESANIS, A. M.
author_facet ROSINSKA, M.
GWIAZDA, P.
DE ANGELIS, D.
PRESANIS, A. M.
author_sort ROSINSKA, M.
collection PubMed
description HIV spread in men who have sex with men (MSM) is an increasing problem in Poland. Despite the existence of a surveillance system, there is no direct evidence to allow estimation of HIV prevalence and the proportion undiagnosed in MSM. We extracted data on HIV and the MSM population in Poland, including case-based surveillance data, diagnostic testing prevalence data and behavioural data relating to self-reported prior diagnosis, stratified by age (⩽35, >35 years) and region (Mazowieckie including the capital city of Warsaw; other regions). They were integrated into one model based on a Bayesian evidence synthesis approach. The posterior distributions for HIV prevalence and the undiagnosed fraction were estimated by Markov Chain Monte Carlo methods. To improve the model fit we repeated the analysis, introducing bias parameters to account for potential lack of representativeness in data. By placing additional constraints on bias parameters we obtained precisely identified estimates. This family of models indicates a high undiagnosed fraction [68·3%, 95% credibility interval (CrI) 53·9–76·1] and overall low prevalence (2·3%, 95% CrI 1·4–4·1) of HIV in MSM. Additional data are necessary in order to produce more robust epidemiological estimates. More effort is urgently needed to ensure timely diagnosis of HIV in Poland.
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spelling pubmed-48251052016-04-20 Bayesian evidence synthesis to estimate HIV prevalence in men who have sex with men in Poland at the end of 2009 ROSINSKA, M. GWIAZDA, P. DE ANGELIS, D. PRESANIS, A. M. Epidemiol Infect Original Papers HIV spread in men who have sex with men (MSM) is an increasing problem in Poland. Despite the existence of a surveillance system, there is no direct evidence to allow estimation of HIV prevalence and the proportion undiagnosed in MSM. We extracted data on HIV and the MSM population in Poland, including case-based surveillance data, diagnostic testing prevalence data and behavioural data relating to self-reported prior diagnosis, stratified by age (⩽35, >35 years) and region (Mazowieckie including the capital city of Warsaw; other regions). They were integrated into one model based on a Bayesian evidence synthesis approach. The posterior distributions for HIV prevalence and the undiagnosed fraction were estimated by Markov Chain Monte Carlo methods. To improve the model fit we repeated the analysis, introducing bias parameters to account for potential lack of representativeness in data. By placing additional constraints on bias parameters we obtained precisely identified estimates. This family of models indicates a high undiagnosed fraction [68·3%, 95% credibility interval (CrI) 53·9–76·1] and overall low prevalence (2·3%, 95% CrI 1·4–4·1) of HIV in MSM. Additional data are necessary in order to produce more robust epidemiological estimates. More effort is urgently needed to ensure timely diagnosis of HIV in Poland. Cambridge University Press 2016-04 2015-11-06 /pmc/articles/PMC4825105/ /pubmed/26542091 http://dx.doi.org/10.1017/S0950268815002538 Text en © Cambridge University Press 2015 http://creativecommons.org/licenses/by/4.0/ This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Papers
ROSINSKA, M.
GWIAZDA, P.
DE ANGELIS, D.
PRESANIS, A. M.
Bayesian evidence synthesis to estimate HIV prevalence in men who have sex with men in Poland at the end of 2009
title Bayesian evidence synthesis to estimate HIV prevalence in men who have sex with men in Poland at the end of 2009
title_full Bayesian evidence synthesis to estimate HIV prevalence in men who have sex with men in Poland at the end of 2009
title_fullStr Bayesian evidence synthesis to estimate HIV prevalence in men who have sex with men in Poland at the end of 2009
title_full_unstemmed Bayesian evidence synthesis to estimate HIV prevalence in men who have sex with men in Poland at the end of 2009
title_short Bayesian evidence synthesis to estimate HIV prevalence in men who have sex with men in Poland at the end of 2009
title_sort bayesian evidence synthesis to estimate hiv prevalence in men who have sex with men in poland at the end of 2009
topic Original Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825105/
https://www.ncbi.nlm.nih.gov/pubmed/26542091
http://dx.doi.org/10.1017/S0950268815002538
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