Cargando…
Reduced folate and serum vitamin metabolites in patients with rectal carcinoma: an open-label feasibility study of pemetrexed with folic acid and vitamin B(12) supplementation
The objectives of this single-center, open-label, phase II study were to evaluate (a) the feasibility and safety of neoadjuvant administration of pemetrexed with oral folic acid and vitamin B(12) (FA/B(12)) in newly diagnosed patients with resectable rectal cancer and (b) intracellular and systemic...
Autores principales: | Stoffregen, Clemens C., Odin, Elisabeth A., Carlsson, Göran U., Kurlberg, Göran K., Björkqvist, Hillevi G., Tångefjord, Maria T., Gustavsson, Bengt G. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825111/ https://www.ncbi.nlm.nih.gov/pubmed/26825869 http://dx.doi.org/10.1097/CAD.0000000000000345 |
Ejemplares similares
-
Phase 1 dose de-escalation trial of the endogenous folate [6R]-5,10-methylene tetrahydrofolate in combination with fixed-dose pemetrexed as neoadjuvant therapy in patients with resectable rectal cancer
por: Gustavsson, Bengt, et al.
Publicado: (2015) -
Relationship between folate concentration and expression of folate-associated genes in tissue and plasma after intraoperative administration of leucovorin in patients with colorectal cancer
por: Taflin, Helena, et al.
Publicado: (2018) -
Effect of Folic Acid and Vitamin B(12) on Pemetrexed Antifolate Chemotherapy in Nutrient Lung Cancer Cells
por: Yang, Tsung-Ying, et al.
Publicado: (2013) -
Folate Levels and Polymorphisms in the Genes MTHFR, MTR, and TS in Colorectal Cancer
por: Taflin, Helena, et al.
Publicado: (2014) -
Plasma deoxyuridine as a surrogate marker for toxicity and early clinical response in patients with metastatic colorectal cancer after 5-FU-based therapy in combination with arfolitixorin
por: Taflin, Helena, et al.
Publicado: (2020)