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Thyroid nodules with minimal cystic changes have a low risk of malignancy

PURPOSE: The goal of this study was to determine the risk of malignancy of thyroid nodules with minimal cystic changes. METHODS: A total of consecutive 1,000 thyroid nodules (≥1 cm) with final diagnoses from twoinstitutions were included in this study. The risk of malignancy of thyroid nodules was a...

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Autores principales: Na, Dong Gyu, Kim, Ji-hoon, Kim, Dae Sik, Kim, Soo Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Ultrasound in Medicine 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825208/
https://www.ncbi.nlm.nih.gov/pubmed/26760848
http://dx.doi.org/10.14366/usg.15070
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author Na, Dong Gyu
Kim, Ji-hoon
Kim, Dae Sik
Kim, Soo Jin
author_facet Na, Dong Gyu
Kim, Ji-hoon
Kim, Dae Sik
Kim, Soo Jin
author_sort Na, Dong Gyu
collection PubMed
description PURPOSE: The goal of this study was to determine the risk of malignancy of thyroid nodules with minimal cystic changes. METHODS: A total of consecutive 1,000 thyroid nodules (≥1 cm) with final diagnoses from twoinstitutions were included in this study. The risk of malignancy of thyroid nodules was analyzed according to the internal content, which was categorized as purely solid, minimally cystic (cystic changes ≤10%), and partially cystic (cystic changes >10%). We also assessed the risk of malignancy of nodules with minimal cystic changes depending on echogenicity and presence of any suspicious ultrasonografic (US) features. RESULTS: The overall frequency of purely solid, minimally cystic, and partially cystic noduleswas 730/1,000 (73%), 61/1,000 (6.1%), and 209/1,000 (20.9%), respectively, with risks ofmalignancy of 14.8% (108/730), 3.3% (2/61), and 3.3% (7/209), respectively. The risk ofmalignancy of nodules with minimal cystic changes was significantly lower than that of purelysolid nodules (P=0.013). The risk of malignancy of nodules with minimal cystic changes was also lower than that of purely solid nodules in the group of hypoechoic nodules (P=0.063) and in the group of nodules with suspicious US features (P=0.028), but was not significantly different from that of partially cystic nodules regardless of echogenicity or the presence of suspicious US features (P≥0.652). CONCLUSION: Thyroid nodules with minimal cystic changes have a low risk of malignancy, similar to that of partially cystic nodules regardless of echogenicity or the presence of suspicious US features. The US lexicon could define solid nodules as nodules with purely solid internal content in order to enhance the accuracy of estimated risks of malignancy.
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spelling pubmed-48252082016-04-11 Thyroid nodules with minimal cystic changes have a low risk of malignancy Na, Dong Gyu Kim, Ji-hoon Kim, Dae Sik Kim, Soo Jin Ultrasonography Original Article PURPOSE: The goal of this study was to determine the risk of malignancy of thyroid nodules with minimal cystic changes. METHODS: A total of consecutive 1,000 thyroid nodules (≥1 cm) with final diagnoses from twoinstitutions were included in this study. The risk of malignancy of thyroid nodules was analyzed according to the internal content, which was categorized as purely solid, minimally cystic (cystic changes ≤10%), and partially cystic (cystic changes >10%). We also assessed the risk of malignancy of nodules with minimal cystic changes depending on echogenicity and presence of any suspicious ultrasonografic (US) features. RESULTS: The overall frequency of purely solid, minimally cystic, and partially cystic noduleswas 730/1,000 (73%), 61/1,000 (6.1%), and 209/1,000 (20.9%), respectively, with risks ofmalignancy of 14.8% (108/730), 3.3% (2/61), and 3.3% (7/209), respectively. The risk ofmalignancy of nodules with minimal cystic changes was significantly lower than that of purelysolid nodules (P=0.013). The risk of malignancy of nodules with minimal cystic changes was also lower than that of purely solid nodules in the group of hypoechoic nodules (P=0.063) and in the group of nodules with suspicious US features (P=0.028), but was not significantly different from that of partially cystic nodules regardless of echogenicity or the presence of suspicious US features (P≥0.652). CONCLUSION: Thyroid nodules with minimal cystic changes have a low risk of malignancy, similar to that of partially cystic nodules regardless of echogenicity or the presence of suspicious US features. The US lexicon could define solid nodules as nodules with purely solid internal content in order to enhance the accuracy of estimated risks of malignancy. Korean Society of Ultrasound in Medicine 2016-04 2015-12-15 /pmc/articles/PMC4825208/ /pubmed/26760848 http://dx.doi.org/10.14366/usg.15070 Text en Copyright © 2016 Korean Society of Ultrasound in Medicine (KSUM) This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Na, Dong Gyu
Kim, Ji-hoon
Kim, Dae Sik
Kim, Soo Jin
Thyroid nodules with minimal cystic changes have a low risk of malignancy
title Thyroid nodules with minimal cystic changes have a low risk of malignancy
title_full Thyroid nodules with minimal cystic changes have a low risk of malignancy
title_fullStr Thyroid nodules with minimal cystic changes have a low risk of malignancy
title_full_unstemmed Thyroid nodules with minimal cystic changes have a low risk of malignancy
title_short Thyroid nodules with minimal cystic changes have a low risk of malignancy
title_sort thyroid nodules with minimal cystic changes have a low risk of malignancy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825208/
https://www.ncbi.nlm.nih.gov/pubmed/26760848
http://dx.doi.org/10.14366/usg.15070
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