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Effect of nonsteroidal anti-inflammatory drugs on colorectal distension-induced visceral pain
OBJECTIVES: To investigate nonsteroidal anti-inflammatory drugs effectiveness in colorectal distension (CRD)-induced visceral pain model. MATERIALS AND METHODS: Male Sprague–Dawley (250–300 g) rats were anesthetized with ketamine (50 mg/kg, intraperitoneally [i.p.]) and chlorpromazine (25 mg/kg, i.p...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825431/ https://www.ncbi.nlm.nih.gov/pubmed/27114637 http://dx.doi.org/10.4103/0253-7613.178830 |
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author | Baskın, Veysel Bilge, S. Sırrı Bozkurt, Ayhan Akyüz, Bahar Ağrı, Arzu Erdal Güzel, Hasan İlkaya, Fatih |
author_facet | Baskın, Veysel Bilge, S. Sırrı Bozkurt, Ayhan Akyüz, Bahar Ağrı, Arzu Erdal Güzel, Hasan İlkaya, Fatih |
author_sort | Baskın, Veysel |
collection | PubMed |
description | OBJECTIVES: To investigate nonsteroidal anti-inflammatory drugs effectiveness in colorectal distension (CRD)-induced visceral pain model. MATERIALS AND METHODS: Male Sprague–Dawley (250–300 g) rats were anesthetized with ketamine (50 mg/kg, intraperitoneally [i.p.]) and chlorpromazine (25 mg/kg, i.p.). Two bipolar Teflon-coated Ni/Cr wire electrodes (80-M diameter) were placed in the abdominal external oblique muscle for the recording of electromyography. Jugular vein catheter was placed for the administration of drugs. CRD method was applied to evaluate of visceral pain. All drugs (paracetamol, meloxicam, metamizole, and dexketoprofen) administered intravenously. RESULTS: Paracetamol 200, 400, and 600 mg/kg did not change the visceromotor response (VMR) when compare with the control group. Meloxicam 2 and 4 mg/kg showed no effect but at doses of 6 mg/kg meloxicam significantly ([51.9 ± 6.4%] [P < 0.001]) decreased VMR compared with the control group. Metamizole 200 mg/kg did not change responses but dose of 400 and 600 mg/kg metamizole reduced VMR. Dexketoprofen 2 and 4 mg/kg did not cause a change in VMR but 6 mg/kg dose significantly reduced response compared with the control group ([43.9 ± 3.9%, 36.8 ± 2.8%, 34.8 ± 2.5%, 42.1 ± 4.8%, 40.7 ± 3.5%, 36.4 ± 2.7%, and 26.1 ± 2.2%]; from 10 min to 70 min, respectively, [P < 0.05]). CONCLUSION: Metamizole, dexketoprofen and meloxicam show antinociceptive effect with different duration of action on CRD-induced visceral pain model. This condition can be explained due to different chemical structures and different mechanisms which play a role in modulation of pain. |
format | Online Article Text |
id | pubmed-4825431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-48254312016-04-25 Effect of nonsteroidal anti-inflammatory drugs on colorectal distension-induced visceral pain Baskın, Veysel Bilge, S. Sırrı Bozkurt, Ayhan Akyüz, Bahar Ağrı, Arzu Erdal Güzel, Hasan İlkaya, Fatih Indian J Pharmacol Research Article OBJECTIVES: To investigate nonsteroidal anti-inflammatory drugs effectiveness in colorectal distension (CRD)-induced visceral pain model. MATERIALS AND METHODS: Male Sprague–Dawley (250–300 g) rats were anesthetized with ketamine (50 mg/kg, intraperitoneally [i.p.]) and chlorpromazine (25 mg/kg, i.p.). Two bipolar Teflon-coated Ni/Cr wire electrodes (80-M diameter) were placed in the abdominal external oblique muscle for the recording of electromyography. Jugular vein catheter was placed for the administration of drugs. CRD method was applied to evaluate of visceral pain. All drugs (paracetamol, meloxicam, metamizole, and dexketoprofen) administered intravenously. RESULTS: Paracetamol 200, 400, and 600 mg/kg did not change the visceromotor response (VMR) when compare with the control group. Meloxicam 2 and 4 mg/kg showed no effect but at doses of 6 mg/kg meloxicam significantly ([51.9 ± 6.4%] [P < 0.001]) decreased VMR compared with the control group. Metamizole 200 mg/kg did not change responses but dose of 400 and 600 mg/kg metamizole reduced VMR. Dexketoprofen 2 and 4 mg/kg did not cause a change in VMR but 6 mg/kg dose significantly reduced response compared with the control group ([43.9 ± 3.9%, 36.8 ± 2.8%, 34.8 ± 2.5%, 42.1 ± 4.8%, 40.7 ± 3.5%, 36.4 ± 2.7%, and 26.1 ± 2.2%]; from 10 min to 70 min, respectively, [P < 0.05]). CONCLUSION: Metamizole, dexketoprofen and meloxicam show antinociceptive effect with different duration of action on CRD-induced visceral pain model. This condition can be explained due to different chemical structures and different mechanisms which play a role in modulation of pain. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4825431/ /pubmed/27114637 http://dx.doi.org/10.4103/0253-7613.178830 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Research Article Baskın, Veysel Bilge, S. Sırrı Bozkurt, Ayhan Akyüz, Bahar Ağrı, Arzu Erdal Güzel, Hasan İlkaya, Fatih Effect of nonsteroidal anti-inflammatory drugs on colorectal distension-induced visceral pain |
title | Effect of nonsteroidal anti-inflammatory drugs on colorectal distension-induced visceral pain |
title_full | Effect of nonsteroidal anti-inflammatory drugs on colorectal distension-induced visceral pain |
title_fullStr | Effect of nonsteroidal anti-inflammatory drugs on colorectal distension-induced visceral pain |
title_full_unstemmed | Effect of nonsteroidal anti-inflammatory drugs on colorectal distension-induced visceral pain |
title_short | Effect of nonsteroidal anti-inflammatory drugs on colorectal distension-induced visceral pain |
title_sort | effect of nonsteroidal anti-inflammatory drugs on colorectal distension-induced visceral pain |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825431/ https://www.ncbi.nlm.nih.gov/pubmed/27114637 http://dx.doi.org/10.4103/0253-7613.178830 |
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