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Replication-induced DNA damage after PARP inhibition causes G(2) delay, and cell line-dependent apoptosis, necrosis and multinucleation
PARP inhibitors have been approved for treatment of tumors with mutations in or loss of BRCA1/2. The molecular mechanisms and particularly the cellular phenotypes resulting in synthetic lethality are not well understood and varying clinical responses have been observed. We have investigated the dose...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825575/ https://www.ncbi.nlm.nih.gov/pubmed/26312527 http://dx.doi.org/10.1080/15384101.2015.1085137 |