Cargando…

X-ray Crystallographic Structure of Oligomers Formed by a Toxic β-Hairpin Derived from α-Synuclein: Trimers and Higher-Order Oligomers

[Image: see text] Oligomeric assemblies of the protein α-synuclein are thought to cause neurodegeneration in Parkinson’s disease and related synucleinopathies. Characterization of α-synuclein oligomers at high resolution is an outstanding challenge in the field of structural biology. The absence of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Salveson, Patrick J., Spencer, Ryan K., Nowick, James S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2016
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825732/ https://www.ncbi.nlm.nih.gov/pubmed/26926877 http://dx.doi.org/10.1021/jacs.5b13261

Ejemplares similares

X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an Aβ(17–36) β-Hairpin
por: Kreutzer, Adam G., et al.
Publicado: (2016)

X-ray Crystallographic Structures of Trimers and Higher-Order Oligomeric Assemblies of a Peptide Derived from Aβ(17–36)
por: Spencer, Ryan K., et al.
Publicado: (2014)

AKAP12 and AKAP5 form higher-order hetero-oligomers
por: Gao, Shujuan, et al.
Publicado: (2011)

The mineralocorticoid receptor forms higher order oligomers upon DNA binding
por: Fettweis, Gregory, et al.
Publicado: (2023)

Lighting Up Alpha-synuclein Oligomers
por: Richter, Franziska
Publicado: (2018)

Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy
por: Gerson, Julia E., et al.
Publicado: (2018)

α-Synuclein Oligomers Induce a Unique Toxic Tau Strain
por: Castillo-Carranza, Diana L., et al.
Publicado: (2018)

Structural Features and Toxicity of α-Synuclein Oligomers Grown in the Presence of DOPAC
por: Palazzi, Luana, et al.
Publicado: (2021)

Direct detection of alpha synuclein oligomers in vivo
por: Dimant, Hemi, et al.
Publicado: (2013)

Alpha-synuclein oligomers: a new hope
por: Bengoa-Vergniory, Nora, et al.
Publicado: (2017)

Quantifying Co-Oligomer Formation by α-Synuclein
por: Iljina, Marija, et al.
Publicado: (2018)

The Role of α-Synuclein Oligomers in Parkinson’s Disease
por: Du, Xiao-yu, et al.
Publicado: (2020)

Stabilization of α-synuclein oligomers using formaldehyde
por: Ruesink, Harm, et al.
Publicado: (2019)

Conformational distortion in a fibril-forming oligomer arrests alpha-Synuclein fibrillation and minimizes its toxic effects
por: Chakraborty, Ritobrita, et al.
Publicado: (2021)

Polymorphism in alpha-synuclein oligomers and its implications in toxicity under disease conditions
por: Yoo, Je Min, et al.
Publicado: (2022)

Probing differences among Aβ oligomers with two triangular trimers derived from Aβ
por: Kreutzer, Adam G., et al.
Publicado: (2023)

Influence of a Hairpin Loop on the Thermodynamic Stability of a DNA Oligomer
por: Lah, Jurij, et al.
Publicado: (2011)

Replication of synthetic recognition-encoded oligomers by ligation of trimer building blocks
por: Núñez-Villanueva, Diego, et al.
Publicado: (2023)

Polymorphism of Oligomers of a Peptide from β-Amyloid
por: Pham, Johnny D., et al.
Publicado: (2014)

Diverse Metastable Structures Formed by Small Oligomers of α-Synuclein Probed by Force Spectroscopy
por: Neupane, Krishna, et al.
Publicado: (2014)

Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers
por: Whiten, Daniel R., et al.
Publicado: (2018)

The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells
por: Cascella, Roberta, et al.
Publicado: (2021)

Exploring the Release of Toxic Oligomers from α-Synuclein Fibrils with Antibodies and STED Microscopy
por: Bigi, Alessandra, et al.
Publicado: (2021)

The Toxicity of Amyloid β Oligomers
por: Zhao, Li Na, et al.
Publicado: (2012)

Exosomal cell-to-cell transmission of alpha synuclein oligomers
por: Danzer, Karin M, et al.
Publicado: (2012)

Structural and functional properties of prefibrillar α-synuclein oligomers
por: Pieri, Laura, et al.
Publicado: (2016)

Optical Structural Analysis of Individual α‐Synuclein Oligomers
por: Varela, Juan A., et al.
Publicado: (2018)

Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale
por: Lee, Ji-Eun, et al.
Publicado: (2018)

Structural and Biophysical Characterization of Stable Alpha-Synuclein Oligomers
por: Vaikath, Nishant, et al.
Publicado: (2022)

α-Synuclein oligomers and fibrils: partners in crime in synucleinopathies
por: Bigi, Alessandra, et al.
Publicado: (2023)

DNA compaction by the higher-order assembly of PRH/Hex homeodomain protein oligomers
por: Soufi, Abdenour, et al.
Publicado: (2010)

A Fibril-Like Assembly of Oligomers of a Peptide Derived from β-Amyloid
por: Pham, Johnny D., et al.
Publicado: (2014)

Modelling Ser129 Phosphorylation Inhibits Membrane Binding of Pore-Forming Alpha-Synuclein Oligomers
por: Nübling, Georg Sebastian, et al.
Publicado: (2014)

X-ray Crystallographic Structure of an Artificial β-Sheet Dimer
por: Khakshoor, Omid, et al.
Publicado: (2010)

Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers
por: Limbocker, Ryan, et al.
Publicado: (2021)

A penetratin-derived peptide reduces the membrane permeabilization and cell toxicity of α-synuclein oligomers
por: Pirhaghi, Mitra, et al.
Publicado: (2022)

Phosphorylation of α-synuclein at T64 results in distinct oligomers and exerts toxicity in models of Parkinson’s disease
por: Matsui, Hideaki, et al.
Publicado: (2023)

Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration
por: Mor, Danielle E., et al.
Publicado: (2017)

Structural characteristics and membrane interactions of tandem α-synuclein oligomers
por: Dong, Chunhua, et al.
Publicado: (2018)

Photo-Induced Cross-Linking of Unmodified α-Synuclein Oligomers
por: Ortigosa-Pascual, Lei, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_v3rooklehkn330pujcaeaba2b3