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PUMA: a puzzle piece in chloroquine’s antimelanoma activity
Chloroquine can induce cell death in a subset of cancer cell lines, and some melanoma cell lines are quite susceptible. While it is well known that chloroquine impairs lysosomal function and can serve as an autophagy inhibitor, the molecular target of chloroquine and the subsequent cascade of events...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825873/ https://www.ncbi.nlm.nih.gov/pubmed/23949767 http://dx.doi.org/10.1038/jid.2013.135 |
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author | Amaravadi, Ravi K. |
author_facet | Amaravadi, Ravi K. |
author_sort | Amaravadi, Ravi K. |
collection | PubMed |
description | Chloroquine can induce cell death in a subset of cancer cell lines, and some melanoma cell lines are quite susceptible. While it is well known that chloroquine impairs lysosomal function and can serve as an autophagy inhibitor, the molecular target of chloroquine and the subsequent cascade of events that leads to cell death are not fully understood. Recent evidence indicates that in melanoma cell lines, chloroquine induces apoptosis by preventing degradation of the pro-apoptotic BH3-only protein PUMA. This finding adds to the unfolding story of chloroquine’s mechanism of action as a cancer therapeutic agent. |
format | Online Article Text |
id | pubmed-4825873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
record_format | MEDLINE/PubMed |
spelling | pubmed-48258732016-04-08 PUMA: a puzzle piece in chloroquine’s antimelanoma activity Amaravadi, Ravi K. J Invest Dermatol Article Chloroquine can induce cell death in a subset of cancer cell lines, and some melanoma cell lines are quite susceptible. While it is well known that chloroquine impairs lysosomal function and can serve as an autophagy inhibitor, the molecular target of chloroquine and the subsequent cascade of events that leads to cell death are not fully understood. Recent evidence indicates that in melanoma cell lines, chloroquine induces apoptosis by preventing degradation of the pro-apoptotic BH3-only protein PUMA. This finding adds to the unfolding story of chloroquine’s mechanism of action as a cancer therapeutic agent. 2013-09 /pmc/articles/PMC4825873/ /pubmed/23949767 http://dx.doi.org/10.1038/jid.2013.135 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Amaravadi, Ravi K. PUMA: a puzzle piece in chloroquine’s antimelanoma activity |
title | PUMA: a puzzle piece in chloroquine’s antimelanoma activity |
title_full | PUMA: a puzzle piece in chloroquine’s antimelanoma activity |
title_fullStr | PUMA: a puzzle piece in chloroquine’s antimelanoma activity |
title_full_unstemmed | PUMA: a puzzle piece in chloroquine’s antimelanoma activity |
title_short | PUMA: a puzzle piece in chloroquine’s antimelanoma activity |
title_sort | puma: a puzzle piece in chloroquine’s antimelanoma activity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825873/ https://www.ncbi.nlm.nih.gov/pubmed/23949767 http://dx.doi.org/10.1038/jid.2013.135 |
work_keys_str_mv | AT amaravadiravik pumaapuzzlepieceinchloroquinesantimelanomaactivity |