A Hox Transcription Factor Collective Binds a Highly Conserved Distal-less cis-Regulatory Module to Generate Robust Transcriptional Outcomes

cis-regulatory modules (CRMs) generate precise expression patterns by integrating numerous transcription factors (TFs). Surprisingly, CRMs that control essential gene patterns can differ greatly in conservation, suggesting distinct constraints on TF binding sites. Here, we show that a highly conserv...

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Detalles Bibliográficos
Autores principales: Uhl, Juli D., Zandvakili, Arya, Gebelein, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825978/
https://www.ncbi.nlm.nih.gov/pubmed/27058369
http://dx.doi.org/10.1371/journal.pgen.1005981

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