The role of the oncofetal H19 lncRNA in tumor metastasis: orchestrating the EMT-MET decision

Long non-coding RNA (lncRNA) genes are emerging as key players in the metastatic cascade. Current evidence indicate that H19 lncRNA and the microRNA(miRNA) miR-675, which is processed from it, play crucial roles in metastasis, through the regulation of critical events specifically the epithelial to...

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Autores principales: Matouk, Imad J., Halle, David, Raveh, Eli, Gilon, Michal, Sorin, Vladimir, Hochberg, Avraham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826167/
https://www.ncbi.nlm.nih.gov/pubmed/26623562
http://dx.doi.org/10.18632/oncotarget.6387
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author Matouk, Imad J.
Halle, David
Raveh, Eli
Gilon, Michal
Sorin, Vladimir
Hochberg, Avraham
author_facet Matouk, Imad J.
Halle, David
Raveh, Eli
Gilon, Michal
Sorin, Vladimir
Hochberg, Avraham
author_sort Matouk, Imad J.
collection PubMed
description Long non-coding RNA (lncRNA) genes are emerging as key players in the metastatic cascade. Current evidence indicate that H19 lncRNA and the microRNA(miRNA) miR-675, which is processed from it, play crucial roles in metastasis, through the regulation of critical events specifically the epithelial to mesenchymal (EMT) and the mesenchymal to epithelial transitions (MET). This review summarizes recent mechanistic pathways and tries to put together seemingly conflicting data from different reports under one proposed general scheme underlying the various roles of H19/miR-675 in the metastatic cascade. We propose several approaches to harnessing this knowledge for translational medicine.
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spelling pubmed-48261672016-05-09 The role of the oncofetal H19 lncRNA in tumor metastasis: orchestrating the EMT-MET decision Matouk, Imad J. Halle, David Raveh, Eli Gilon, Michal Sorin, Vladimir Hochberg, Avraham Oncotarget Review Long non-coding RNA (lncRNA) genes are emerging as key players in the metastatic cascade. Current evidence indicate that H19 lncRNA and the microRNA(miRNA) miR-675, which is processed from it, play crucial roles in metastasis, through the regulation of critical events specifically the epithelial to mesenchymal (EMT) and the mesenchymal to epithelial transitions (MET). This review summarizes recent mechanistic pathways and tries to put together seemingly conflicting data from different reports under one proposed general scheme underlying the various roles of H19/miR-675 in the metastatic cascade. We propose several approaches to harnessing this knowledge for translational medicine. Impact Journals LLC 2015-11-25 /pmc/articles/PMC4826167/ /pubmed/26623562 http://dx.doi.org/10.18632/oncotarget.6387 Text en Copyright: © 2016 Matouk et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Matouk, Imad J.
Halle, David
Raveh, Eli
Gilon, Michal
Sorin, Vladimir
Hochberg, Avraham
The role of the oncofetal H19 lncRNA in tumor metastasis: orchestrating the EMT-MET decision
title The role of the oncofetal H19 lncRNA in tumor metastasis: orchestrating the EMT-MET decision
title_full The role of the oncofetal H19 lncRNA in tumor metastasis: orchestrating the EMT-MET decision
title_fullStr The role of the oncofetal H19 lncRNA in tumor metastasis: orchestrating the EMT-MET decision
title_full_unstemmed The role of the oncofetal H19 lncRNA in tumor metastasis: orchestrating the EMT-MET decision
title_short The role of the oncofetal H19 lncRNA in tumor metastasis: orchestrating the EMT-MET decision
title_sort role of the oncofetal h19 lncrna in tumor metastasis: orchestrating the emt-met decision
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826167/
https://www.ncbi.nlm.nih.gov/pubmed/26623562
http://dx.doi.org/10.18632/oncotarget.6387
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