High efficacy of third generation EGFR inhibitor AZD9291 in a leptomeningeal carcinomatosis model with EGFR-mutant lung cancer cells

Leptomeningeal carcinomatosis (LMC) remarkably decreases the quality of life of EGFR-mutant lung cancer patients. In contrast to the lesions outside the central nervous system (CNS), molecular mechanisms of EGFR tyrosine kinase inhibitor (TKI) resistance in CNS lesions including LMC are largely unkn...

Descripción completa

Detalles Bibliográficos
Autores principales: Nanjo, Shigeki, Ebi, Hiromichi, Arai, Sachiko, Takeuchi, Shinji, Yamada, Tadaaki, Mochizuki, Satsuki, Okada, Yasunori, Nakada, Mitsutoshi, Murakami, Takashi, Yano, Seiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826174/
https://www.ncbi.nlm.nih.gov/pubmed/26716903
http://dx.doi.org/10.18632/oncotarget.6758

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826174/
https://www.ncbi.nlm.nih.gov/pubmed/26716903
http://dx.doi.org/10.18632/oncotarget.6758

Ejemplares similares