Cargando…

Overexpression of wildtype EGFR is tumorigenic and denotes a therapeutic target in non-small cell lung cancer

Current guidelines for lung cancer treatment with EGFR tyrosine kinase inhibitors (TKI) include only patients with mutated EGFR, although some patients with wildtype EGFR (wt-EGFR) have exhibited positive responses to this therapy as well. Biomarkers predicting the benefit from EGFR-TKIs treatment r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Naiqing, Fang, Wenfeng, Mu, Libing, Tang, Yanna, Gao, Lei, Ren, Shengxiang, Cao, Dengfeng, Zhou, Lixin, Zhang, Aiqun, Liu, Deruo, Zhou, Caicun, Wong, Kwok-Kin, Yu, Lei, Zhang, Li, Chen, Liang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826177/ https://www.ncbi.nlm.nih.gov/pubmed/26646697 http://dx.doi.org/10.18632/oncotarget.6461

Ejemplares similares

Correction: Overexpression of wildtype EGFR is tumorigenic and denotes a therapeutic target in non-small cell lung cancer
por: Xu, Naiqing, et al.
Publicado: (2018)

A tumor suppressor enhancing module orchestrated by GATA4 denotes a therapeutic opportunity for GATA4 deficient HCC patients
por: Lu, Feng, et al.
Publicado: (2020)

MiR-200c overexpression is associated with better efficacy of EGFR-TKIs in non-small cell lung cancer patients with EGFR wild-type
por: Li, Jiayu, et al.
Publicado: (2014)

Bisphosphonates enhance antitumor effect of EGFR-TKIs in patients with advanced EGFR mutant NSCLC and bone metastases
por: Zhang, Guowei, et al.
Publicado: (2017)

The Cambrian cirratuliform Iotuba denotes an early annelid radiation
por: Zhang, ZhiFei, et al.
Publicado: (2023)

Overexpression of Suprabasin is Associated with Proliferation and Tumorigenicity of Esophageal Squamous Cell Carcinoma
por: Zhu, Jinrong, et al.
Publicado: (2016)

Gene expression rearrangements denoting changes in the biological state
por: Gonzalez, Augusto, et al.
Publicado: (2021)

Arginine off-kilter: guanidinium is not as planar as restraints denote
por: Moriarty, Nigel W., et al.
Publicado: (2020)

First-line continual EGFR-TKI plus local ablative therapy demonstrated survival benefit in EGFR-mutant NSCLC patients with oligoprogressive disease
por: Xu, Qinghua, et al.
Publicado: (2019)

Epidemiological study of HER-2 mutations among EGFR wild-type lung adenocarcinoma patients in China
por: Li, Xuefei, et al.
Publicado: (2016)

Genetic insights into thymic carcinomas and thymic neuroendocrine neoplasms denote prognosis signatures and pathways
por: Wang, Shuyuan, et al.
Publicado: (2023)

Addition of bevacizumab for malignant pleural effusion as the manifestation of acquired EGFR-TKI resistance in NSCLC patients
por: Jiang, Tao, et al.
Publicado: (2017)

Distribution and favorable prognostic implication of genomic EGFR alterations in IDH ‐wildtype glioblastoma
por: Higa, Nayuta, et al.
Publicado: (2022)

Soluble PD-L1 as a Predictor of the Response to EGFR-TKIs in Non-small Cell Lung Cancer Patients With EGFR Mutations
por: Jia, Yijun, et al.
Publicado: (2020)

EMT-Induced Stemness and Tumorigenicity Are Fueled by the EGFR/Ras Pathway
por: Voon, Dominic Chih-Cheng, et al.
Publicado: (2013)

Ayurveda support for health prevention in post crisis, nuclear denotation
por: Wiwanitkit, Viroj
Publicado: (2011)

Nuclear denotation: A topic for global public health concern
por: Wiwanitkit, Viroj
Publicado: (2011)

Pulmonary disorder and present nuclear denotation: A brief summary
por: Wiwanitkit, Viroj
Publicado: (2011)

Reverse AD at Higher Types: Pure, Principled and Denotationally Correct
por: Vákár, Matthijs
Publicado: (2021)

PIK3CA Mutations Frequently Coexist with EGFR/KRAS Mutations in Non-Small Cell Lung Cancer and Suggest Poor Prognosis in EGFR/KRAS Wildtype Subgroup
por: Wang, Lei, et al.
Publicado: (2014)

The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma
por: Diplas, Bill H., et al.
Publicado: (2018)

An immune signature to predict the prognosis of ATRX-wildtype glioma patients and guide immune checkpoint blockade therapy
por: Cao, Wenpeng, et al.
Publicado: (2023)

Sex Differences in Neural Activation to Facial Expressions Denoting Contempt and Disgust
por: Aleman, André, et al.
Publicado: (2008)

Prolotherapy of the temporomandibular joint is denoted as a new health technology in Korea
por: Lee, Won
Publicado: (2023)

Distinct histone modifications denote early stress-induced drug tolerance in cancer
por: Emran, Abdullah Al, et al.
Publicado: (2017)

Wildtype epidermal growth factor receptor (Egfr) is not required for daily locomotor or masking behavior in mice
por: Roberts, Reade B, et al.
Publicado: (2006)

MicroRNA-1229 overexpression promotes cell proliferation and tumorigenicity and activates Wnt/β-catenin signaling in breast cancer
por: Tan, Zhanyao, et al.
Publicado: (2016)

The impact of EGFR exon 19 deletion subtypes on clinical outcomes in non-small cell lung cancer
por: Zhao, Chao, et al.
Publicado: (2020)

Health communication implications of the perceived meanings of terms used to denote unhealthy foods
por: Pettigrew, Simone, et al.
Publicado: (2017)

Multiple productive IGH rearrangements denote oligoclonality even in immunophenotypically monoclonal CLL
por: Brazdilova, K, et al.
Publicado: (2018)

Approaches to denote treatment outcome: Clinical significance and clinical global impression compared
por: de Beurs, Edwin, et al.
Publicado: (2019)

False‐positive bone scintigraphy denoting transthyretin amyloid in elderly hypertrophic cardiomyopathy
por: Chimenti, Cristina, et al.
Publicado: (2021)

Isoforms of Neuropilin-2 Denote Unique Tumor-Associated Macrophages in Breast Cancer
por: Dhupar, Rajeev, et al.
Publicado: (2022)

MicroRNA-138 Overexpression Alters Aβ42 Levels and Behavior in Wildtype Mice
por: Boscher, Emmanuelle, et al.
Publicado: (2021)

Pan‐cancer analysis identifies TERT alterations as predictive biomarkers for immune checkpoint inhibitors treatment
por: Jiang, Tao, et al.
Publicado: (2020)

Clinical features and therapeutic options in non‐small cell lung cancer patients with concomitant mutations of EGFR, ALK, ROS1, KRAS or BRAF
por: Zhuang, Xibin, et al.
Publicado: (2019)

Blocking interaction between SHP2 and PD‐1 denotes a novel opportunity for developing PD‐1 inhibitors
por: Fan, Zhenzhen, et al.
Publicado: (2020)

Ribociclib Induces Broad Chemotherapy Resistance and EGFR Dependency in ESR1 Wildtype and Mutant Breast Cancer
por: Mayayo-Peralta, Isabel, et al.
Publicado: (2021)

Overexpression of SIRT6 attenuates the tumorigenicity of hepatocellular carcinoma cells
por: Wang, Yadong, et al.
Publicado: (2017)

Interleukin-10 induces expression of CD39 on CD8+T cells to potentiate anti-PD1 efficacy in EGFR-mutated non-small cell lung cancer
por: Qiao, Meng, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3k312a7erejacnrbcv7cpreiao