Genetic deletion of osteopontin in TRAMP mice skews prostate carcinogenesis from adenocarcinoma to aggressive human-like neuroendocrine cancers

Osteopontin (OPN) is a secreted glycoprotein, that belongs to the non-structural extracellular matrix (ECM), and its over expression in human prostate cancer has been associated with disease progression, androgen independence and metastatic ability. Nevertheless, the pathophysiology of OPN in prosta...

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Detalles Bibliográficos
Autores principales: Mauri, Giorgio, Jachetti, Elena, Comuzzi, Barbara, Dugo, Matteo, Arioli, Ivano, Miotti, Silvia, Sangaletti, Sabina, Di Carlo, Emma, Tripodo, Claudio, Colombo, Mario P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826179/
https://www.ncbi.nlm.nih.gov/pubmed/26700622
http://dx.doi.org/10.18632/oncotarget.6678

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