Combination therapy of RY10-4 with the γ-secretase inhibitor DAPT shows promise in treating HER2-amplified breast cancer

RY10-4, a novel protoapigenone analog, shows potent cytotoxicity against human breast cancer cells. However, breast cancer cell lines overexpressing human epidermal growth factor receptor 2 (HER2), SKBR3 and BT474, showed less sensitivity to RY10-4 when compared to breast cancer cells lines expressi...

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Detalles Bibliográficos
Autores principales: Su, Feng, Zhu, Shilin, Ruan, Jinlan, Muftuoglu, Yagmur, Zhang, Longbo, Yuan, Qianying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826195/
https://www.ncbi.nlm.nih.gov/pubmed/26716652
http://dx.doi.org/10.18632/oncotarget.6769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826195/
https://www.ncbi.nlm.nih.gov/pubmed/26716652
http://dx.doi.org/10.18632/oncotarget.6769

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