Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule

Restoration of the p53 pathway, namely by reactivation of mutant (mut) p53, represents a valuable anticancer strategy. Herein, we report the identification of the enantiopure tryptophanol-derived oxazoloisoindolinone SLMP53-1 as a novel reactivator of wild-type (wt) and mut p53, using a yeast-based...

Descripción completa

Detalles Bibliográficos
Autores principales: Soares, Joana, Raimundo, Liliana, Pereira, Nuno A.L., Monteiro, Ângelo, Gomes, Sara, Bessa, Cláudia, Pereira, Clara, Queiroz, Glória, Bisio, Alessandra, Fernandes, João, Gomes, Célia, Reis, Flávio, Gonçalves, Jorge, Inga, Alberto, Santos, Maria M.M., Saraiva, Lucília
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826208/
https://www.ncbi.nlm.nih.gov/pubmed/26735173
http://dx.doi.org/10.18632/oncotarget.6775

Ejemplares similares

Ejemplares similares