Emodin potentiates the antiproliferative effect of interferon α/β by activation of JAK/STAT pathway signaling through inhibition of the 26S proteasome

The 26S proteasome is a negative regulator of type I interferon (IFN-α/β) signaling. Inhibition of the 26S proteasome by small molecules may be a new strategy to enhance the efficacy of type I IFNs and reduce their side effects. Using cell-based screening assay for new 26S proteasome inhibitors, we...

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Detalles Bibliográficos
Autores principales: He, Yujiao, Huang, Junmei, Wang, Ping, Shen, Xiaofei, Li, Sheng, Yang, Lijuan, Liu, Wanli, Suksamrarn, Apichart, Zhang, Guolin, Wang, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826234/
https://www.ncbi.nlm.nih.gov/pubmed/26683360
http://dx.doi.org/10.18632/oncotarget.6616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826234/
https://www.ncbi.nlm.nih.gov/pubmed/26683360
http://dx.doi.org/10.18632/oncotarget.6616

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