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Emodin potentiates the antiproliferative effect of interferon α/β by activation of JAK/STAT pathway signaling through inhibition of the 26S proteasome

The 26S proteasome is a negative regulator of type I interferon (IFN-α/β) signaling. Inhibition of the 26S proteasome by small molecules may be a new strategy to enhance the efficacy of type I IFNs and reduce their side effects. Using cell-based screening assay for new 26S proteasome inhibitors, we...

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Detalles Bibliográficos
Autores principales:	He, Yujiao, Huang, Junmei, Wang, Ping, Shen, Xiaofei, Li, Sheng, Yang, Lijuan, Liu, Wanli, Suksamrarn, Apichart, Zhang, Guolin, Wang, Fei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826234/ https://www.ncbi.nlm.nih.gov/pubmed/26683360 http://dx.doi.org/10.18632/oncotarget.6616

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