Type II toxin: antitoxin systems. More than small selfish entities?

Toxin–antitoxin (TA) modules regulate metabolism and viability of bacteria and archaea. In type II TA systems these functions are generally thought to be performed by two small proteins. However, evidence is increasing that the toxins are much more diverse and can form multi-domain proteins. Recentl...

Descripción completa

Detalles Bibliográficos
Autores principales: Rocker, Andrea, Meinhart, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826407/
https://www.ncbi.nlm.nih.gov/pubmed/26597447
http://dx.doi.org/10.1007/s00294-015-0541-7
_version_ 1782426328234983424
author Rocker, Andrea
Meinhart, Anton
author_facet Rocker, Andrea
Meinhart, Anton
author_sort Rocker, Andrea
collection PubMed
description Toxin–antitoxin (TA) modules regulate metabolism and viability of bacteria and archaea. In type II TA systems these functions are generally thought to be performed by two small proteins. However, evidence is increasing that the toxins are much more diverse and can form multi-domain proteins. Recently, we published a novel type II TA system in which toxin and antitoxin are covalently linked into a single polypeptide chain. In this review we summarize the current knowledge on these elongated toxin homologs and provide perspectives for future study.
format Online
Article
Text
id pubmed-4826407
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-48264072016-04-20 Type II toxin: antitoxin systems. More than small selfish entities? Rocker, Andrea Meinhart, Anton Curr Genet Review Toxin–antitoxin (TA) modules regulate metabolism and viability of bacteria and archaea. In type II TA systems these functions are generally thought to be performed by two small proteins. However, evidence is increasing that the toxins are much more diverse and can form multi-domain proteins. Recently, we published a novel type II TA system in which toxin and antitoxin are covalently linked into a single polypeptide chain. In this review we summarize the current knowledge on these elongated toxin homologs and provide perspectives for future study. Springer Berlin Heidelberg 2015-11-23 2016 /pmc/articles/PMC4826407/ /pubmed/26597447 http://dx.doi.org/10.1007/s00294-015-0541-7 Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Rocker, Andrea
Meinhart, Anton
Type II toxin: antitoxin systems. More than small selfish entities?
title Type II toxin: antitoxin systems. More than small selfish entities?
title_full Type II toxin: antitoxin systems. More than small selfish entities?
title_fullStr Type II toxin: antitoxin systems. More than small selfish entities?
title_full_unstemmed Type II toxin: antitoxin systems. More than small selfish entities?
title_short Type II toxin: antitoxin systems. More than small selfish entities?
title_sort type ii toxin: antitoxin systems. more than small selfish entities?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826407/
https://www.ncbi.nlm.nih.gov/pubmed/26597447
http://dx.doi.org/10.1007/s00294-015-0541-7
work_keys_str_mv AT rockerandrea typeiitoxinantitoxinsystemsmorethansmallselfishentities
AT meinhartanton typeiitoxinantitoxinsystemsmorethansmallselfishentities

Ejemplares similares