Automated quantification of proliferation with automated hot-spot selection in phosphohistone H3/MART1 dual-stained stage I/II melanoma

BACKGROUND: Staging of melanoma includes quantification of a proliferation index, i.e., presumed melanocytic mitoses of H&E stains are counted manually in hot spots. Yet, its reproducibility and prognostic impact increases by immunohistochemical dual staining for phosphohistone H3 (PHH3) and MAR...

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Detalles Bibliográficos
Autores principales: Nielsen, Patricia Switten, Riber-Hansen, Rikke, Schmidt, Henrik, Steiniche, Torben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826493/
https://www.ncbi.nlm.nih.gov/pubmed/27062658
http://dx.doi.org/10.1186/s13000-016-0484-4

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