GnRH agonist triggering affects the kinetics of embryo development: a comparative study

BACKGROUND: To evaluate the effects of an ovulation triggering agent, human chorionic gonadotropin (hCG), versus a gonadotropin-releasing hormone agonist (GnRHa) on early embryo development in vitro using a time-lapse system. METHODS: Retrospective analysis of a prospectively collected database. A t...

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Autores principales: Gurbuz, Ali Sami, Gode, Funda, Uzman, Mehmet Sukru, Ince, Betul, Kaya, Melek, Ozcimen, Necati, Ozcimen, Emel Ebru, Acar, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826504/
https://www.ncbi.nlm.nih.gov/pubmed/27059823
http://dx.doi.org/10.1186/s13048-016-0229-8
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author Gurbuz, Ali Sami
Gode, Funda
Uzman, Mehmet Sukru
Ince, Betul
Kaya, Melek
Ozcimen, Necati
Ozcimen, Emel Ebru
Acar, Ali
author_facet Gurbuz, Ali Sami
Gode, Funda
Uzman, Mehmet Sukru
Ince, Betul
Kaya, Melek
Ozcimen, Necati
Ozcimen, Emel Ebru
Acar, Ali
author_sort Gurbuz, Ali Sami
collection PubMed
description BACKGROUND: To evaluate the effects of an ovulation triggering agent, human chorionic gonadotropin (hCG), versus a gonadotropin-releasing hormone agonist (GnRHa) on early embryo development in vitro using a time-lapse system. METHODS: Retrospective analysis of a prospectively collected database. A total of 739 embryos from 152 infertile couples undergoing intracytoplasmic sperm injection cycles. Interventions : Embryo culture in a time-lapse incubator (EmbryoScope, Vitrolife, Göteborg, Sweden). Main Outcome Measures: Embryo morphokinetic parameters. RESULTS: In the 152 women, 252 embryos were derived from GnRHa-triggered cycles compared with 487 embryos derived from hCG-triggered cycles. Time-lapse analysis revealed that embryos from cycles triggered by a GnRHa cleaved faster than embryos derived from hCG-triggered cycles. CONCLUSION: Triggering with a GnRHa in in vitro fertilization cycles affects embryo kinetics.
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spelling pubmed-48265042016-04-10 GnRH agonist triggering affects the kinetics of embryo development: a comparative study Gurbuz, Ali Sami Gode, Funda Uzman, Mehmet Sukru Ince, Betul Kaya, Melek Ozcimen, Necati Ozcimen, Emel Ebru Acar, Ali J Ovarian Res Research BACKGROUND: To evaluate the effects of an ovulation triggering agent, human chorionic gonadotropin (hCG), versus a gonadotropin-releasing hormone agonist (GnRHa) on early embryo development in vitro using a time-lapse system. METHODS: Retrospective analysis of a prospectively collected database. A total of 739 embryos from 152 infertile couples undergoing intracytoplasmic sperm injection cycles. Interventions : Embryo culture in a time-lapse incubator (EmbryoScope, Vitrolife, Göteborg, Sweden). Main Outcome Measures: Embryo morphokinetic parameters. RESULTS: In the 152 women, 252 embryos were derived from GnRHa-triggered cycles compared with 487 embryos derived from hCG-triggered cycles. Time-lapse analysis revealed that embryos from cycles triggered by a GnRHa cleaved faster than embryos derived from hCG-triggered cycles. CONCLUSION: Triggering with a GnRHa in in vitro fertilization cycles affects embryo kinetics. BioMed Central 2016-04-08 /pmc/articles/PMC4826504/ /pubmed/27059823 http://dx.doi.org/10.1186/s13048-016-0229-8 Text en © Gurbuz et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Gurbuz, Ali Sami
Gode, Funda
Uzman, Mehmet Sukru
Ince, Betul
Kaya, Melek
Ozcimen, Necati
Ozcimen, Emel Ebru
Acar, Ali
GnRH agonist triggering affects the kinetics of embryo development: a comparative study
title GnRH agonist triggering affects the kinetics of embryo development: a comparative study
title_full GnRH agonist triggering affects the kinetics of embryo development: a comparative study
title_fullStr GnRH agonist triggering affects the kinetics of embryo development: a comparative study
title_full_unstemmed GnRH agonist triggering affects the kinetics of embryo development: a comparative study
title_short GnRH agonist triggering affects the kinetics of embryo development: a comparative study
title_sort gnrh agonist triggering affects the kinetics of embryo development: a comparative study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826504/
https://www.ncbi.nlm.nih.gov/pubmed/27059823
http://dx.doi.org/10.1186/s13048-016-0229-8
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