Cargando…

A computational method for designing diverse linear epitopes including citrullinated peptides with desired binding affinities to intravenous immunoglobulin

BACKGROUND: Understanding the interactions between antibodies and the linear epitopes that they recognize is an important task in the study of immunological diseases. We present a novel computational method for the design of linear epitopes of specified binding affinity to Intravenous Immunoglobulin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Patro, Rob, Norel, Raquel, Prill, Robert J., Saez-Rodriguez, Julio, Lorenz, Peter, Steinbeck, Felix, Ziems, Bjoern, Luštrek, Mitja, Barbarini, Nicola, Tiengo, Alessandra, Bellazzi, Riccardo, Thiesen, Hans-Jürgen, Stolovitzky, Gustavo, Kingsford, Carl
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826543/ https://www.ncbi.nlm.nih.gov/pubmed/27059896 http://dx.doi.org/10.1186/s12859-016-1008-7

Ejemplares similares

Epitope Predictions Indicate the Presence of Two Distinct Types of Epitope-Antibody-Reactivities Determined by Epitope Profiling of Intravenous Immunoglobulins
por: Luštrek, Mitja, et al.
Publicado: (2013)

Prediction of Peptide Reactivity with Human IVIg through a Knowledge-Based Approach
por: Barbarini, Nicola, et al.
Publicado: (2011)

Correction: Prediction of Peptide Reactivity with Human IVIg through a Knowledge-Based Approach
por: Barbarini, Nicola, et al.
Publicado: (2011)

Stratification of clear cell renal cell carcinoma (ccRCC) genomes by gene-directed copy number alteration (CNA) analysis
por: Thiesen, H.-J., et al.
Publicado: (2017)

Epitope Specificity of Anti-Citrullinated Protein Antibodies
por: Trier, Nicole H., et al.
Publicado: (2017)

Antibodies to carbamylated α-enolase epitopes in rheumatoid arthritis also bind citrullinated epitopes and are largely indistinct from anti-citrullinated protein antibodies
por: Reed, Evan, et al.
Publicado: (2016)

Specificity of Anti-Citrullinated Protein Antibodies to Citrullinated α-Enolase Peptides as a Function of Epitope Structure and Composition
por: Fanelli, Ilaria, et al.
Publicado: (2021)

Physical Characteristics of a Citrullinated Pro-Filaggrin Epitope Recognized by Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis Sera
por: Trier, Nicole Hartwig, et al.
Publicado: (2016)

PhosphoHunter: An Efficient Software Tool for Phosphopeptide Identification
por: Tiengo, Alessandra, et al.
Publicado: (2015)

A procedure to decompose high resolution mass spectra
por: Barbarini, Nicola, et al.
Publicado: (2007)

Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination
por: Kidd, Brian A, et al.
Publicado: (2008)

The self-assessment trap: can we all be better than average?
por: Norel, Raquel, et al.
Publicado: (2011)

Epitope Fine Mapping by Mass Spectrometry: Investigations of Immune Complexes Consisting of Monoclonal Anti‐HpTGEKP Antibody and Zinc Finger Protein Linker Phospho‐Hexapeptides
por: Scherf, Maximilian, et al.
Publicado: (2022)

Using Markov Chains and Multi-Objective Optimization for Energy-Efficient Context Recognition †
por: Janko, Vito, et al.
Publicado: (2017)

A General Framework for Making Context-Recognition Systems More Energy Efficient †
por: Janko, Vito, et al.
Publicado: (2021)

Phenome‐Wide Association Study of Autoantibodies to Citrullinated and Noncitrullinated Epitopes in Rheumatoid Arthritis
por: Liao, Katherine P., et al.
Publicado: (2017)

Citrullination modulates antigen processing and presentation by revealing cryptic epitopes in rheumatoid arthritis
por: Curran, Ashley M., et al.
Publicado: (2023)

A Perl procedure for protein identification by Peptide Mass Fingerprinting
por: Tiengo, Alessandra, et al.
Publicado: (2009)

The KRAB Domain of ZNF10 Guides the Identification of Specific Amino Acids That Transform the Ancestral KRAB-A-Related Domain Present in Human PRDM9 into a Canonical Modern KRAB-A Domain
por: Lorenz, Peter, et al.
Publicado: (2022)

Affinity Purification and Comparative Biosensor Analysis of Citrulline-Peptide-Specific Antibodies in Rheumatoid Arthritis
por: Szarka, Eszter, et al.
Publicado: (2018)

The increased ability to present citrullinated peptides is not unique to HLA-SE molecules: arginine-to-citrulline conversion also enhances peptide affinity for HLA-DQ molecules
por: Kampstra, Arieke S. B., et al.
Publicado: (2016)

Fine-specificity of the antibodies against citrullinated protein response is influenced by shared epitope alleles
por: Verpoort, KN, et al.
Publicado: (2007)

Antibodies to synthetic citrullinated peptide epitope correlate with disease activity and flares in rheumatoid arthritis
por: Khatri, Sangita, et al.
Publicado: (2020)

Clinical Implications of Shared Epitope and Anti-citrullinated Peptide Antibody in Patients With Rheumatoid Arthritis
por: Jung, Seung Min, et al.
Publicado: (2022)

Hierarchical Naive Bayes for genetic association studies
por: Malovini, Alberto, et al.
Publicado: (2012)

DUF3669, a “domain of unknown function” within ZNF746 and ZNF777, oligomerizes and contributes to transcriptional repression
por: Al Chiblak, Mohannad, et al.
Publicado: (2019)

Blood Pressure Estimation from Photoplethysmogram Using a Spectro-Temporal Deep Neural Network
por: Slapničar, Gašper, et al.
Publicado: (2019)

Classification of Hemodynamics Scenarios from a Public Radar Dataset Using a Deep Learning Approach
por: Slapničar, Gašper, et al.
Publicado: (2021)

Predicting protein interactions via parsimonious network history inference
por: Patro, Rob, et al.
Publicado: (2013)

Data-dependent bucketing improves reference-free compression of sequencing reads
por: Patro, Rob, et al.
Publicado: (2015)

Reference-based compression of short-read sequences using path encoding
por: Kingsford, Carl, et al.
Publicado: (2015)

Affinity purified anti-citrullinated protein/peptide antibodies target antigens expressed in the rheumatoid joint
por: Ossipova, Elena, et al.
Publicado: (2014)

Development of a Novel Bioinformatics Tool for In Silico Validation of Protein Interactions
por: Barbarini, Nicola, et al.
Publicado: (2010)

Mapping of citrullinated fibrinogen B-cell epitopes in rheumatoid arthritis by imaging surface plasmon resonance
por: van Beers, Joyce JBC, et al.
Publicado: (2010)

Epitope-Based Chicken-Derived Novel Anti-PAD2 Monoclonal Antibodies Inhibit Citrullination
por: Aosasa, Masayoshi, et al.
Publicado: (2021)

The Role of Shared Epitope in Rheumatoid Arthritis Prognosis in Relation to Anti-Citrullinated Protein Antibody Positivity
por: Zhuo, Joe, et al.
Publicado: (2022)

Computational Design of High-Affinity Epitope Scaffolds by Backbone Grafting of a Linear Epitope
por: Azoitei, Mihai L., et al.
Publicado: (2012)

Immune Recognition of Citrullinated Proteoglycan Aggrecan Epitopes in Mice with Proteoglycan-Induced Arthritis and in Patients with Rheumatoid Arthritis
por: Markovics, Adrienn, et al.
Publicado: (2016)

How Accurately Can Your Wrist Device Recognize Daily Activities and Detect Falls?
por: Gjoreski, Martin, et al.
Publicado: (2016)

Smartwatch-Based Eating Detection: Data Selection for Machine Learning from Imbalanced Data with Imperfect Labels
por: Stankoski, Simon, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_lb6032ivn10fm3i76efhvj1ggh