Caspase activity and apoptotic signaling in proliferating C2C12 cells following cisplatin or A23187 exposure

Investigating cell death signaling using cell culture is commonly performed to examine the effects of novel pharmaceuticals or to further characterize discrete cellular signaling pathways. Here, we provide data regarding the cell death response to either cisplatin or A23187 in sub-confluent C2C12 ce...

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Detalles Bibliográficos
Autores principales: Bloemberg, Darin, Quadrilatero, Joe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826590/
https://www.ncbi.nlm.nih.gov/pubmed/27104214
http://dx.doi.org/10.1016/j.dib.2016.03.032
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author Bloemberg, Darin
Quadrilatero, Joe
author_facet Bloemberg, Darin
Quadrilatero, Joe
author_sort Bloemberg, Darin
collection PubMed
description Investigating cell death signaling using cell culture is commonly performed to examine the effects of novel pharmaceuticals or to further characterize discrete cellular signaling pathways. Here, we provide data regarding the cell death response to either cisplatin or A23187 in sub-confluent C2C12 cells, by utilizing several concentrations and incubation times for each chemical. These data include an assessment of the activation of the proteolytic enzymes caspase-3, caspase-8, caspase-9, calpain, and cathepsin B/L. Additionally, the expression of the apoptosis-regulating proteins Bax, Bcl2, and p53 are presented.
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spelling pubmed-48265902016-04-21 Caspase activity and apoptotic signaling in proliferating C2C12 cells following cisplatin or A23187 exposure Bloemberg, Darin Quadrilatero, Joe Data Brief Data Article Investigating cell death signaling using cell culture is commonly performed to examine the effects of novel pharmaceuticals or to further characterize discrete cellular signaling pathways. Here, we provide data regarding the cell death response to either cisplatin or A23187 in sub-confluent C2C12 cells, by utilizing several concentrations and incubation times for each chemical. These data include an assessment of the activation of the proteolytic enzymes caspase-3, caspase-8, caspase-9, calpain, and cathepsin B/L. Additionally, the expression of the apoptosis-regulating proteins Bax, Bcl2, and p53 are presented. Elsevier 2016-03-12 /pmc/articles/PMC4826590/ /pubmed/27104214 http://dx.doi.org/10.1016/j.dib.2016.03.032 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Data Article
Bloemberg, Darin
Quadrilatero, Joe
Caspase activity and apoptotic signaling in proliferating C2C12 cells following cisplatin or A23187 exposure
title Caspase activity and apoptotic signaling in proliferating C2C12 cells following cisplatin or A23187 exposure
title_full Caspase activity and apoptotic signaling in proliferating C2C12 cells following cisplatin or A23187 exposure
title_fullStr Caspase activity and apoptotic signaling in proliferating C2C12 cells following cisplatin or A23187 exposure
title_full_unstemmed Caspase activity and apoptotic signaling in proliferating C2C12 cells following cisplatin or A23187 exposure
title_short Caspase activity and apoptotic signaling in proliferating C2C12 cells following cisplatin or A23187 exposure
title_sort caspase activity and apoptotic signaling in proliferating c2c12 cells following cisplatin or a23187 exposure
topic Data Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826590/
https://www.ncbi.nlm.nih.gov/pubmed/27104214
http://dx.doi.org/10.1016/j.dib.2016.03.032
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